代谢组学：对心血管研究和疾病的影响。

IF 8 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Reviews Pub Date : 2024-10-06 DOI:10.1111/obr.13825

Amir Ajoolabady, Domenico Pratico, Warwick B. Dunn, Gregory Y. H. Lip, Jun Ren

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引用次数: 0

摘要

细胞代谢影响着细胞功能的方方面面，对整个机体的健康至关重要。与心血管健康有关的代谢紊乱可导致心血管疾病（CVD）。此外，相关的并发症也会损害心血管代谢，加剧心血管疾病，使恶性循环持续下去。鉴于代谢改变在心血管疾病中的突出作用，代谢组学已成为一项必要的技术，可对体内代谢物和代谢结构进行全面评估。代谢物图谱和代谢途径有助于加深和拓宽我们对心血管疾病复杂基因组图谱和病理生理学的理解。在这篇综述中，我们旨在概述代谢组学在各种心血管疾病的发病机制、诊断、预后和管理方面的实验和临床应用，以及未来的前景和局限性。

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Metabolomics: Implication in cardiovascular research and diseases

Cellular metabolism influences all aspects of cellular function and is crucial for overall organismal health. Metabolic disorders related to cardiovascular health can lead to cardiovascular diseases (CVDs). Moreover, associated comorbidities may also damage cardiovascular metabolism, exacerbating CVD and perpetuating a vicious cycle. Given the prominent role of metabolic alterations in CVD, metabolomics has emerged as an imperative technique enabling a comprehensive assessment of metabolites and metabolic architecture within the body. Metabolite profile and metabolic pathways help to deepen and broaden our understanding of complex genomic landscape and pathophysiology of CVD. Here in this review, we aim to overview the experimental and clinical applications of metabolomics in pathogenesis, diagnosis, prognosis, and management of various CVD plus future perspectives and limitations.

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来源期刊

Obesity Reviews 医学-内分泌学与代谢

CiteScore

19.30

自引率

1.10%

发文量

130

审稿时长

1 months

期刊介绍： Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities. Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field. The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.