癌症中的 MUC16/CA125：新进展

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2024-10-04 DOI:10.1016/j.cca.2024.119981

Xin-Yu Zhang , Lian-Lian Hong , Zhi-Qiang Ling

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引用次数: 0

摘要

MUC16/CA125 是多种类型腺癌的常见诊断标志物。然而，由于 MUC16 在癌症中的广泛表达，其作为靶点的特异性和敏感性较差，严重限制了其临床应用。近年来，各种研究表明，MUC16/CA125 的临床应用潜力已大大提高。检测技术的更新提高了检测的准确性和范围，提高了癌症的早期诊断率。靶向 MUC16/CA125 是肿瘤治疗的重要策略。靶向 MUC16 细胞表面的残余氨基酸或 n-糖基化结构，或与其他靶点相结合，可大大提高检测和治疗的准确性。新的给药方法突破了原有的技术桎梏，更有针对性地靶向MUC16阳性细胞，提高了药物疗效。本文详细介绍了MUC16靶点检测和鉴定的技术进展以及基于MUC16靶点的癌症筛查和治疗的巨大进步，揭示了MUC16作为靶点在癌症筛查和治疗中的巨大潜力，说明了MUC16潜在的临床应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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MUC16/CA125 in cancer: new advances

MUC16/CA125 is a common diagnostic marker for many types of cancer. However, due to the widespread expression of MUC16 in cancer, its specificity and sensitivity as a target are poor, which severely limits its clinical application. In recent years, various studies have shown that the clinical application potential of MUC16/CA125 has been greatly improved. The update of detection technology improves the accuracy and range of detection, and improves the early diagnosis rate of cancer. Targeting MUC16/CA125 is an important strategy for tumor therapy. Targeting residual amino acids, n-glycoylation structures or other targets on the surface of MUC16 cells can greatly improve the accuracy of detection and therapy. The new drug delivery method broke through the original technical shackles, targeted MUC16 positive cells more specifically and improved the drug efficacy. In this paper, the technological advances in detecting and identifying MUC16 targets and the great progress in cancer screening and treatment based on MUC16 as a target are described in detail, revealing the great potential of MUC16 as a target in cancer screening and treatment, and illustrating the potential clinical application value of MUC16.

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.