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Chevalierlin：一种来自热液喷口伴生真菌 Aspergillus chevalieri TW132-65 的螺环生物碱。

IF 3.2 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Phytochemistry Pub Date : 2024-10-03 DOI:10.1016/j.phytochem.2024.114295
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引用次数: 0

摘要

从一种与热液喷口有关的真菌 Aspergillus chevalieri TW132-65 的培养物中分离出了一种以前未曾描述过的螺二酮哌嗪吲哚生物碱 chevalierlin (1)、两对以前未曾描述过的二氢异香豆素对映体 eurotiumides H-I (2-3) 以及六种相关的已知化合物 (4-9)。通过核磁共振、质谱和 ECD 计算，这些化合物的结构被明确确定。Chevalierlin (1) 对 Namalwa 和 Raji 细胞株具有中等程度的细胞毒性活性，IC50 值分别为 6.20 ± 0.05 μM 和 7.68 ± 0.01 μM。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chevalierlin: A spirocyclic alkaloid from a hydrothermal vent associated fungus Aspergillus chevalieri TW132-65

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Chevalierlin: A spirocyclic alkaloid from a hydrothermal vent associated fungus Aspergillus chevalieri TW132-65
A previously undescribed spirodiketopiperazine-indole alkaloid, chevalierlin (1), two pairs of previously undescribed dihydroisocoumarin enantiomers eurotiumides H–I (2–3), as well as six related known compounds (4–9) were isolated from the culture of a hydrothermal vent associated fungus Aspergillus chevalieri TW132-65. Their structures were unambiguously determined by NMR, mass spectrometry, and ECD calculations. Chevalierlin (1) exhibits moderate cytotoxic activities with IC50 values of 6.20 ± 0.05 μM and 7.68 ± 0.01 μM against Namalwa and Raji cell lines.
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来源期刊
Phytochemistry
Phytochemistry 生物-植物科学
CiteScore
6.40
自引率
7.90%
发文量
443
审稿时长
39 days
期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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