支持和调节中性粒细胞效应功能的碳水化合物代谢。

IF 6.6 2区 医学 Q1 IMMUNOLOGY
Jorgo Lika , Jing Fan
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引用次数: 0

摘要

中性粒细胞是先天性免疫系统的第一反应器,激活后可开启一系列效应功能。最新研究表明,活化的中性粒细胞会进行高度动态的新陈代谢重新布线。这种新陈代谢重新布线为效应功能提供能量和还原力,并调节信号分子以调控中性粒细胞的功能。在此,我们回顾了目前对中性粒细胞迁移、中性粒细胞胞外捕获物释放和病原体杀伤的特定代谢要求和调节因素的理解。特别是,我们讨论了主要的碳水化合物代谢途径,包括糖酵解、糖原循环、磷酸戊糖途径和 TCA 循环,是如何在中性粒细胞激活时重新连接以支持这些功能的。继续研究嗜中性粒细胞功能的代谢调节因子可为各种疾病带来治疗机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carbohydrate metabolism in supporting and regulating neutrophil effector functions
Neutrophils, the first responders of the innate immune system, can turn on a range of effector functions upon activation. Emerging research shows activated neutrophils undergo highly dynamic metabolic rewiring. This metabolic rewiring provides energy and reducing power to fuel effector functions and modulate signaling molecules to regulate neutrophil functions. Here, we review the current understanding of the specific metabolic requirements and regulators of neutrophil migration, neutrophil extracellular traps release, and pathogen killing. Particularly, we discuss how major carbohydrate metabolic pathways, including glycolysis, glycogen cycling, pentose phosphate pathway, and TCA cycle, are rewired upon neutrophil activation to support these functions. Continued investigation into the metabolic regulators of neutrophil functions can lead to therapeutic opportunities in various diseases.
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来源期刊
CiteScore
13.30
自引率
1.40%
发文量
94
审稿时长
67 days
期刊介绍: Current Opinion in Immunology aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Immunology we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. Current Opinion in Immunology will serve as an invaluable source of information for researchers, lecturers, teachers, professionals, policy makers and students. Current Opinion in Immunology builds on Elsevier''s reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health. It is a companion to the new Gold Open Access journal Current Research in Immunology and is part of the Current Opinion and Research(CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists'' workflow.
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