在精神分裂症大鼠模型中，两种不同的富集住所可不同程度地改善物体和地点识别障碍。

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2024-10-02 DOI:10.1016/j.bbr.2024.115276

Michimasa Toyoshima , Katsumasa Takahashi , Eri Sato , Shota Shimoda, Kazuo Yamada

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引用次数: 0

摘要

精神分裂症是一种以认知功能障碍为特征的精神疾病。这些功能障碍严重影响了精神分裂症患者的日常生活，但有效的干预措施仍然很少。在这项研究中，我们探讨了认知和物理两种丰富的居住类型对精神分裂症大鼠模型认知功能障碍的影响。雄性新生 Wistar-Imamichi 大鼠从出生后第 7 天到第 20 天每天两次服用非竞争性 NMDAR 拮抗剂 MK-801。身体强化改善了物体和地点识别测试中的记忆缺陷，而认知强化主要提高了物体识别能力。我们的研究结果表明，运动疗法可能是解决精神分裂症患者认知功能障碍的一种潜在方法。

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Two distinct enriched housings differentially ameliorate object and place recognition deficits in a rat model of schizophrenia

Schizophrenia is a psychiatric disorder characterized by cognitive dysfunctions. These dysfunctions significantly impact the daily lives of schizophrenic patients, yet effective interventions remain scarce. In this study, we explored the effects of two enriched housing types—cognitive and physical—on cognitive dysfunctions in a rat model of schizophrenia. Male neonatal Wistar-Imamichi rats were administered MK-801, a noncompetitive NMDAR antagonist, twice daily from postnatal day (PND) 7 to PND 20. Physical enrichment ameliorated memory deficits in both object and place recognition tests, while cognitive enrichment primarily improved object recognition performance. Our findings suggest that exercise therapy could be a potential approach to address cognitive dysfunctions in schizophrenia patients.

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.