烷基砜：以囊泡乙酰胆碱转运体为目标的新型化学支架开创了新一代杀虫剂。

IF 3.8 1区农林科学 Q1 AGRONOMY

Pest Management Science Pub Date : 2024-10-05 DOI:10.1002/ps.8462

Robert A Holland, Andrew Crossthwaite

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引用次数: 0

摘要

以神经系统为靶标的杀虫剂由于起效快，可有效保护作物，因此一直被最广泛地用于控制节肢动物害虫。随着杀虫剂的不断使用，抗药性已经并将成为一个不可避免的挑战，这就要求我们继续努力识别和开发作用于新靶标的新型杀虫化学药剂。在最近发表的一篇文章中，介绍了对基于 2-（3-乙基磺酰基-2-吡啶基）三环烷基砜的新型化学支架的作用模式进行综合研究的结果，得出的结论是它们的主要靶标是囊泡乙酰胆碱转运体。© 2024 化学工业协会。

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Alkylsulfones: novel chemical scaffolds targeting the vesicular acetylcholine transporter usher in a new generation of insecticides.

Insecticides targeting the nervous system have been the most widely used to control arthropod pests due to their fast onset of action leading to efficient crop protection. With their continued use, resistance has and will become an inevitable challenge that demands continued efforts in identifying and developing new insecticidal chemistries acting on novel targets. In a recent publication, the results of a comprehensive study investigating the mode of action of novel chemical scaffolds based on the 2-(3-ethylsulfonyl-2-pyridyl)-heterocycles, alkylsulfones, was presented, concluding that their primary target is the vesicular acetylcholine transporter. © 2024 Society of Chemical Industry.

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.