强调少突胶质细胞需要淋巴管

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2024-10-04 DOI:10.1038/s41593-024-01778-1

Shari Wiseman

引用次数: 0

摘要

众所周知，脑膜淋巴系统能调节神经免疫功能，但它如何影响驻留脑细胞却不太清楚。在最近发表于《免疫》（Immunity）的一篇论文中，das Neves 等人通过干扰 VEGF-C/D 信号传导，部分消减了小鼠的脑膜淋巴管。这导致了胼胝体和运动皮层中成熟少突胶质细胞（MOL）的减少，以及脑脂质组成的破坏。在这些细胞消失之前，单细胞转录组学发现了成熟少突胶质细胞基因表达的改变，包括代谢和氧化应激基因。在缺乏中枢神经系统相关成熟T细胞和B细胞的小鼠或中枢神经系统相关先天性免疫细胞的小鼠中，淋巴管消融对MOLs的影响并不明显。此外，淋巴管被消融的小鼠从铜绿素诱导的脱髓鞘中恢复过来的速度比完整的小鼠慢。沿着这些思路，作者观察到多发性硬化症患者脑脊液样本中的 VEGF-C 水平降低，这表明人类脱髓鞘疾病可能涉及脑膜淋巴管的损伤：免疫 https://doi.org/10.1016/j.immuni.2024.08.004 (2024)

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.