计算机辅助评估无视网膜病变的镰状细胞病患儿的视网膜血管迂曲情况。

IF 2.9 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2024-10-01 DOI:10.1016/j.mvr.2024.104752

Lina H. Raffa , Enass H. Raffa , Álvaro S. Hervella , Lucía Ramos , Jorge Novo , José Rouco , Marcos Ortega

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引用次数: 0

摘要

目的我们评估了从无明显视网膜病变的镰状细胞病（SCD）患者眼底图片中自动量化视网膜血管迂曲的预测效果：使用眼底成像技术获取了 31 名健康患者和 31 名 SCD 患者的视网膜图像，并使用新型计算自动度量评估技术进行了分析。根据图像分析了局部和整体血管迂曲度及其与全身疾病参数的关系：结果：与对照组相比，SCD动脉的局部迂曲指数增加（0.0007 ± 0.0019 vs. 0.0006 ± 0.0014，p = 0.019）。此外，SCD 患者的血管口径更宽，主要是在动脉方面（14.68 ± 5.3 vs. 14.06 ± 5.3，p 结论：SCD 患者的血管口径更宽，主要是在动脉方面（14.68 ± 5.3 vs. 14.06 ± 5.3，p 结论）：视网膜动脉迂曲度和口径是可靠和客观的测量指标，可用作镰状细胞视网膜病变的无创预后和诊断指标。需要进一步研究这些局部血管参数与全身风险因素之间的关系，并监测它们随时间的进展和变化。

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Computer-assisted evaluation of retinal vessel tortuosity in children with sickle cell disease without retinopathy

Objective

We assessed the predictive efficacy of automatically quantified retinal vascular tortuosity from the fundus pictures of patients with sickle cell disease (SCD) without evident retinopathy.

Methods

Retinal images were obtained from 31 healthy and 31 SCD participants using fundus imaging and analyzed using a novel computational automated metric assessment. The local and global vessel tortuosity and their relationship with systemic disease parameters were analyzed based on the images.

Results

SCD arteries had an increased local tortuosity index compared to the controls (0.0007 ± 0.0019 vs. 0.0006 ± 0.0014, p = 0.019). Furthermore, the SCD patients had wider vessel caliber mainly in the arteries (14.68 ± 5.3 vs. 14.06 ± 5.3, p < 0.001). The SCD global tortuosity did not differ significantly from that of the controls (p = 0.598). The female participants had significantly reduced retinal vessel tortuosity indices compared to the male participants (p = 0.018).

Conclusion

Retinal arterial tortuosity and caliber were reliable and objective measures that could be used as a non-invasive prognostic and diagnostic indicator in sickle cell retinopathy. Further studies are required to correlate these local vascular parameters to systemic risk factors and monitor their progression and change over time.

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来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.