血清 hsa_tsr011468 在肺腺癌中的作用和临床价值

IF 3.4 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Molecular medicine reports Pub Date : 2024-12-01 Epub Date: 2024-10-04 DOI:10.3892/mmr.2024.13350
Ping Zhao, Kui Zhu, Cuihua Xie, Sinan Liu, Xiang Chen
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引用次数: 0

摘要

转运RNA衍生的小RNA(tsRNA)是一种新型非编码RNA,与多种疾病的发病机制有关。然而,它们与肺腺癌(LUAD)的关系尚未得到全面研究。因此,本研究旨在探讨一种名为 hsa_tsr011468 的 tsRNA 在 LUAD 中的诊断价值。本研究利用 OncotRF 数据库筛选 tsRNA,并通过反转录定量 PCR(RT-qPCR)检测 hsa_tsr011468 在不同样本中的表达水平。随后,通过接收者操作特征曲线(ROC)和生存曲线分析以及临床病理参数评估,确定了 hsa_tsr011468 对 LUAD 的诊断和预后价值。此外,还提取了细胞核和细胞质 RNA 以评估 hsa_tsr011468 的位置。OncotRF数据库确定了hsa_tsr011468在LUAD中的高表达。此外,RT-qPCR结果显示,hsa_tsr011468在LUAD患者血清和组织中的相对表达水平高于正常对照组。此外,其在 LUAD 患者术后血清样本中的表达低于术前血清样本。ROC和生存曲线表明,hsa_tsr011468具有良好的诊断和预后价值。此外,临床病理分析表明,hsa_tsr011468 与肿瘤大小有关。此外,hsa_tsr011468主要定位于LUAD细胞的胞浆中。本研究表明,hsa_tsr011468具有良好的诊断价值,因此可用作LUAD的血清标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role and clinical value of serum hsa_tsr011468 in lung adenocarcinoma.

Transfer RNA‑derived small RNAs (tsRNAs) are novel non‑coding RNAs that are associated with the pathogenesis of various diseases. However, their association with lung adenocarcinoma (LUAD) has not been studied comprehensively. Therefore, the present study aimed to explore the diagnostic value of a tsRNA, hsa_tsr011468, in LUAD. The OncotRF database was used to screen tsRNAs and reverse transcription‑quantitative PCR (RT‑qPCR) was performed to detect the expression levels of hsa_tsr011468 in various samples. Subsequently, the diagnostic and prognostic values of hsa_tsr011468 for LUAD were determined via receiver operating characteristic (ROC) curve and survival curve analyses, and by assessing clinicopathological parameters. In addition, both nuclear and cytoplasmic RNA were extracted to assess the location of hsa_tsr011468. The OncotRF database identified high expression of hsa_tsr011468 in LUAD. In addition, the results of RT‑qPCR showed that the relative expression levels of hsa_tsr011468 in the serum and tissues of patients with LUAD were higher than those in normal controls. Furthermore, its expression was lower in postoperative serum samples than in preoperative serum samples from patients with LUAD. ROC and survival curves indicated that hsa_tsr011468 had good diagnostic and prognostic value. Furthermore, the clinicopathological analysis revealed that hsa_tsr011468 was associated with tumor size. In addition, hsa_tsr011468 was mainly localized in the cytoplasm of LUAD cells. The present study indicated that hsa_tsr011468 has good diagnostic value and, therefore, could be employed as a serum marker for LUAD.

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来源期刊
Molecular medicine reports
Molecular medicine reports 医学-病理学
CiteScore
7.60
自引率
0.00%
发文量
321
审稿时长
1.5 months
期刊介绍: Molecular Medicine Reports is a monthly, peer-reviewed journal available in print and online, that includes studies devoted to molecular medicine, underscoring aspects including pharmacology, pathology, genetics, neurosciences, infectious diseases, molecular cardiology and molecular surgery. In vitro and in vivo studies of experimental model systems pertaining to the mechanisms of a variety of diseases offer researchers the necessary tools and knowledge with which to aid the diagnosis and treatment of human diseases.
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