一名乳腺癌患者的免疫球蛋白 A 主导型膜增生性肾小球肾炎样损伤模式可能是一种副肿瘤性肾病。

IF 1 Q4 UROLOGY & NEPHROLOGY
Shuntaro Taira, Mika Kawagoe, Hitoshi Anzai, Minoru Yasukawa, Shinichiro Asakawa, Shigeyuki Arai, Osamu Yamazaki, Yoshifuru Tamura, Yasutoshi Oshima, Satoe Numakura, Ryuji Ohashi, Shigeru Shibata, Yoshihide Fujigaki
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引用次数: 0

摘要

一位中年女性在一次健康检查中被发现有蛋白尿。大约 16 个月后,她被诊断为右乳腺 IIA 期浸润性导管癌。她的蛋白尿发展为肾病综合征,并伴有明显血尿。她开始接受激素治疗,以治疗雌激素和孕激素受体阳性的乳腺癌。在开始治疗 47 天后进行的肾活检显示,她的肾脏出现了 IgA 主导的膜增生性肾小球肾炎样损伤。电子显微镜检查显示以内皮下电子密度沉积(EDD)为主,伴有少量系膜电子密度沉积和一次上皮下驼峰样电子密度沉积,以及偶尔的系膜穿插。IgA血管炎伴肾炎、IgA主导型感染相关性肾小球肾炎和肝病相关性肾小球病变也可引起类似的病理变化,但这些病理变化均已排除。沉积的 IgA 被发现是半乳糖缺陷 IgA1。因此,考虑是伴有肾小球毛细血管 IgA 沉积的 IgA 肾病。在开始接受激素治疗 75 天后,她接受了右侧乳房部分切除术和右侧腋窝前哨淋巴结活检,随后接受了辅助放射治疗。治疗后,蛋白尿和血尿有减少的趋势,即使在开始激素治疗 156 天后因肾小球肾炎接受皮质类固醇治疗,这一趋势仍在继续。在开始接受激素治疗约 15 个月后,她的蛋白尿降至每克肌酐 1.0 克左右,血尿呈阴性。众所周知,伴有肾小球毛细血管 IgA 沉积的 IgA 肾病对皮质类固醇治疗具有耐药性。这种罕见的肾小球病在乳腺癌治疗后的良好临床过程表明,我们的患者被诊断为继发于乳腺癌的副肿瘤性肾小球病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunoglobulin A-dominant membranoproliferative glomerulonephritis-like pattern of injury as a possible paraneoplastic nephropathy in a breast cancer patient.

A middle-aged woman was found to have proteinuria during a health check-up. About sixteen months later, she was diagnosed with stage IIA invasive ductal carcinoma of the right breast. Her proteinuria progressed to nephrotic syndrome with significant hematuria. Hormone therapy was initiated for her estrogen and progesterone receptor-positive breast cancer. A kidney biopsy performed 47 days after starting the therapy revealed an IgA-dominant membranoproliferative glomerulonephritis-like pattern of injury. Electron microscopy showed subendothelial-dominant electron-dense deposits (EDD), with small amounts of mesangial EDD and a single occurrence of subepithelial hump-like EDD, along with occasional mesangial interpositions. Similar pathology can be caused by IgA vasculitis with nephritis, IgA-dominant infection-associated glomerulonephritis, and liver disease-associated glomerulopathy, but all of these were ruled out. The deposited IgA was found to be galactose-deficient IgA1. Thus, IgA nephropathy with glomerular capillary IgA deposition was considered. She underwent a right partial mastectomy and sentinel lymph node biopsy in the right axilla 75 days after starting hormone therapy, followed by adjuvant radiation. Proteinuria and hematuria tended to decrease after the treatment, and this trend continued even after corticosteroid therapy for glomerulonephritis, which was administered 156 days after starting hormone therapy. Approximately 15 months after starting hormone therapy, her proteinuria had reduced to around 1.0 g/g of creatinine, and her hematuria was negative. IgA nephropathy with glomerular capillary IgA deposition is known to be resistant to corticosteroid therapy. The favorable clinical course of the rare glomerulopathy following breast cancer treatment suggested a diagnosis of paraneoplastic glomerulopathy secondary to breast cancer in our patient.

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来源期刊
CEN Case Reports
CEN Case Reports UROLOGY & NEPHROLOGY-
CiteScore
1.90
自引率
0.00%
发文量
80
期刊介绍: Clinical and Experimental Nephrology (CEN) Case Reports is a peer-reviewed online-only journal, officially published biannually by the Japanese Society of Nephrology (JSN).  The journal publishes original case reports in nephrology and related areas.  The purpose of CEN Case Reports is to provide clinicians and researchers with a forum in which to disseminate their personal experience to a wide readership and to review interesting cases encountered by colleagues all over the world, from whom contributions are welcomed.
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