非编码 RNA 与糖尿病肾病

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-10-03 DOI:10.1111/jdi.14331

Jun Wada

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引用次数: 0

摘要

在人类临床和动物实验研究中，通过对各种血清、血浆、全血和组织样本的研究，发现了糖尿病及其并发症中调控 RNA（如 miRNA、lncRNA 和 circRNA）表达的改变。这些已发现的 ncRNA 是疾病诊断标志物、预后标志物和治疗靶点的候选者。本报告将讨论最近发表的与 DKD 发病和进展有关的 ncRNAs。

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Noncoding RNAs and diabetic kidney disease.

In both human clinical and animal experimental studies, the altered expression of regulatory RNAs such as miRNAs, lncRNAs, and circRNAs are reported in diabetes and its complications by investigating various samples of serum, plasma, whole blood, and tissues. These identified ncRNAs are candidates for the disease diagnostic markers, prognostic markers, and also therapeutic targets. In the updates, the recently published ncRNAs involved in the onset and progression of DKD are discussed.

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).