PRC2-RNA 相互作用：李容宇和李贞妮的观点

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-10-03 DOI:10.1016/j.molcel.2024.09.006

YongWoo Lee, Jeannie T. Lee

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引用次数: 0

摘要

在这里，我们阐述了 Xist RNA 直接控制多聚核酸抑制复合体 2（PRC2）的招募、卸载到染色质、催化活性以及从染色质中驱逐的观点。RNA-PRC2 的相互作用还控制着 RNA 聚合酶 II 的转录暂停。RNA 的动态折叠决定了 PRC2 的活性。不同的研究和解释比比皆是，但都是可以调和的。

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PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee

Here, we expound on the view that Xist RNA directly controls Polycomb repressive complex 2 (PRC2) recruitment, off-loading to chromatin, catalytic activity, and eviction from chromatin. RNA-PRC2 interactions also control RNA polymerase II transcription pausing. Dynamic RNA folding determines PRC2 activity. Disparate studies and interpretations abound but can be reconciled.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.