Kazuhiko Hashimoto, Tomohiko Ito, Yuto Yamagishi, Koji Goto
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引用次数: 0
摘要
一名 54 岁的女性在 8 年前患上 IV 期乳腺癌。她接受了化疗，并开始使用唑来膦酸治疗骨转移。随后，由于疾病进展，她的化疗方案进行了调整。在开始使用唑来膦酸治疗 57 个月后，患者右股骨发生非典型股骨骨折，并接受了手术治疗。20 个月后，她的左股骨又发生了非典型股骨骨折，并接受了髓内钉固定术。考虑到非典型股骨骨折的风险，乳腺癌转移性骨肿瘤患者应谨慎使用唑来膦酸和地诺单抗。
Bilateral atypical femur fracture in a patient with breast cancer taking zoledronic acid and denosumab: a case report.
A 54-year-old woman developed stage IV breast cancer 8 years prior. Chemotherapy was administered, and she was started on zoledronic acid treatment for her bone metastases. Her chemotherapy regimen was then switched, owing to disease progression. Fifty-seven months after starting treatment with zoledronic acid, the patient suffered an atypical femoral fracture of her right femur, for which she underwent surgery. Twenty months later, she developed another atypical femoral fracture in her left femur and underwent intramedullary nail fixation. Zoledronic acid and denosumab use in patients with metastatic bone tumors caused by breast cancer should be done cautiously, considering atypical femoral fracture risk.
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