将长非编码 RNA H19 作为肝病治疗策略的靶点

IF 3.2 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Progress in Biophysics & Molecular Biology Pub Date : 2024-09-30 DOI:10.1016/j.pbiomolbio.2024.09.005

Yulan Shi , Fenghua Qu , Shiyun Zeng , Xinchen Wang , Yuting Liu , Qirui Zhang , Ding Yuan , Chengfu Yuan

{"title":"将长非编码 RNA H19 作为肝病治疗策略的靶点","authors":"Yulan Shi , Fenghua Qu , Shiyun Zeng , Xinchen Wang , Yuting Liu , Qirui Zhang , Ding Yuan , Chengfu Yuan","doi":"10.1016/j.pbiomolbio.2024.09.005","DOIUrl":null,"url":null,"abstract":"<div><div>The liver has the function of regulating metabolic equilibrium in the human body, and the majority of liver disorders are chronic conditions that can significantly impair health. Recent research has highlighted the critical role of long noncoding RNAs (lncRNAs) in liver disease pathogenesis. LncRNA H19, an endogenous noncoding single-stranded RNA, exerts its influence through epigenetic modifications and affects various biological processes. This review focuses on elucidating the key molecular mechanisms underlying the regulation of H19 during the progression and advancement of liver diseases, aiming to highlight H19 as a potential therapeutic target and provide profound insights into the molecular underpinnings of liver pathologies.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 1-9"},"PeriodicalIF":3.2000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Targeting long non-coding RNA H19 as a therapeutic strategy for liver disease\",\"authors\":\"Yulan Shi , Fenghua Qu , Shiyun Zeng , Xinchen Wang , Yuting Liu , Qirui Zhang , Ding Yuan , Chengfu Yuan\",\"doi\":\"10.1016/j.pbiomolbio.2024.09.005\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The liver has the function of regulating metabolic equilibrium in the human body, and the majority of liver disorders are chronic conditions that can significantly impair health. Recent research has highlighted the critical role of long noncoding RNAs (lncRNAs) in liver disease pathogenesis. LncRNA H19, an endogenous noncoding single-stranded RNA, exerts its influence through epigenetic modifications and affects various biological processes. This review focuses on elucidating the key molecular mechanisms underlying the regulation of H19 during the progression and advancement of liver diseases, aiming to highlight H19 as a potential therapeutic target and provide profound insights into the molecular underpinnings of liver pathologies.</div></div>\",\"PeriodicalId\":54554,\"journal\":{\"name\":\"Progress in Biophysics & Molecular Biology\",\"volume\":\"194 \",\"pages\":\"Pages 1-9\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in Biophysics & Molecular Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0079610724000919\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Biophysics & Molecular Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0079610724000919","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

肝脏具有调节人体新陈代谢平衡的功能，而大多数肝脏疾病都是慢性病，会严重损害人体健康。最近的研究强调了长非编码 RNA（lncRNA）在肝病发病机制中的关键作用。LncRNA H19是一种内源性非编码单链RNA，通过表观遗传修饰发挥影响，并影响各种生物过程。本综述重点阐明肝脏疾病进展和恶化过程中 H19 调控的关键分子机制，旨在突出 H19 作为潜在治疗靶点的作用，并对肝脏病变的分子基础提供深刻的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Targeting long non-coding RNA H19 as a therapeutic strategy for liver disease

查看原文本刊更多论文

Targeting long non-coding RNA H19 as a therapeutic strategy for liver disease

The liver has the function of regulating metabolic equilibrium in the human body, and the majority of liver disorders are chronic conditions that can significantly impair health. Recent research has highlighted the critical role of long noncoding RNAs (lncRNAs) in liver disease pathogenesis. LncRNA H19, an endogenous noncoding single-stranded RNA, exerts its influence through epigenetic modifications and affects various biological processes. This review focuses on elucidating the key molecular mechanisms underlying the regulation of H19 during the progression and advancement of liver diseases, aiming to highlight H19 as a potential therapeutic target and provide profound insights into the molecular underpinnings of liver pathologies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Progress in Biophysics & Molecular Biology 生物-生化与分子生物学

CiteScore

8.60

自引率

7.90%

发文量

审稿时长

85 days

期刊介绍： Progress in Biophysics & Molecular Biology is an international review journal and covers the ground between the physical and biological sciences since its launch in 1950. It indicates to the physicist the great variety of unsolved problems awaiting attention in biology and medicine. The biologist and biochemist will find that this journal presents new and stimulating ideas and novel approaches to studying and influencing structural and functional properties of the living organism. This journal will be of particular interest to biophysicists, biologists, biochemists, cell physiologists, systems biologists, and molecular biologists.