质子密度脂肪分数定量法（PD-FFQ）：用于成人造血能力评估和再生障碍性水肿诊断的能力。

IF 2.1 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging Pub Date : 2024-09-29 DOI:10.1016/j.mri.2024.110240

Yoshiharu Ohno , Takahiro Ueda , Masahiko Nomura , Yuichiro Sano , Kaori Yamamoto , Maiko Shinohara , Masato Ikedo , Masao Yui , Akiyoshi Iwase , Hiroyuki Nagata , Takeshi Yoshikawa , Daisuke Takenaka , Akihiro Tomita , Nobuyuki Fujita , Yoshiyuki Ozawa

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引用次数: 0

摘要

目的：本研究旨在确定质子密度与脂肪分数（PD-FFQ）成像在帮助评估成人造血能力和诊断再生障碍性贫血方面的能力：方法：2021年1月至2023年3月期间，对确诊为再生障碍性贫血（AA：n = 14）或骨髓增生异常综合征（MDS：n = 14）的患者进行全身质子密度脂肪分数（PD-FFQ）成像检查，并从126名年龄和性别匹配、接受过相同质子密度脂肪分数（PD-FFQ）成像检查的患者中选取14名作为对照组。然后使用感兴趣区（ROI）对所有质子密度脂肪分数（PDFF）指数进行评估。使用皮尔逊相关性来确定血液检测结果与各项定量指标之间的关系，并使用基于 ROC 的阳性测试和判别分析来比较区分 AA 组和非 AA 组的能力。最后，通过 McNemar 检验比较了所有定量指标的敏感性、特异性和准确性：结果：椎体的 PDFF 平均值、标准偏差（SD）和变异系数百分比（%CV）与血液检测结果有显著相关性（-0.52 ≤ r ≤ -0.34，p 结论：PD-FF-X 光成像技术可用于区分 AA 组和非 AA 组：全身 PD-FFQ 成像可用于成人造血能力评估和再生障碍性贫血的诊断。

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Proton Density Fat Fraction Quantification (PD-FFQ): Capability for hematopoietic ability assessment and aplastic anemaia diagnosis of adults

Purpose

The purpose of this study was to determine the capability of proton density with fat fraction (PD-FFQ) imaging to help assess hematopoietic ability and diagnose aplastic anemia in adults.

Methods

Between January 2021 and March 2023, patients diagnosed with aplastic anemia (AA: n = 14) or myelodysplastic syndrome (MDS: n = 14) were examined by whole-body PD-FFQ imaging, and 14 of 126 age and gender matched patients who had undergone the same PD-FFQ imaging were selected as control group. All proton density fat fraction (PDFF) index evaluations were then performed by using regions of interest (ROIs). Pearson's correlation was used to determine the relationship between blood test results and each quantitative index, and ROC-based positive test and discrimination analyses to compare capability to differentiate the AA from the non-AA group. Finally, sensitivity, specificity and accuracy of all quantitative indexes were compared by means of McNemar's test.

Results

Mean PDFF, standard deviation (SD) and percentage of coefficient of variation (%CV) for vertebrae showed significant correlation with blood test results (−0.52 ≤ r ≤ −0.34, p < 0.05). Specificity (SP) and accuracy (AC) of %CV of PDFF in vertebrae were significantly higher than those of mean PDFF in vertebrae and the posterior superior iliac spine (SP: p = 0.0002, AC: p = 0.0001) and SD of PDFF in vertebrae (SP: p = 0.008, AC: p = 0.008). Moreover, AC of SD of PDFF in vertebrae was significantly higher than that of mean PDFF in vertebrae and the posterior superior iliac spine (p = 0.03).

Conclusion

Whole-body PD-FFQ imaging is useful for hematopoietic ability assessment and diagnosis of aplastic anemia in adults.

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来源期刊

Magnetic resonance imaging 医学-核医学

CiteScore

4.70

自引率

4.00%

发文量

194

审稿时长

83 days

期刊介绍： Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.