新生小牛大脑中的许旺病。

IF 1.2 3区 农林科学 Q3 VETERINARY SCIENCES
Diana Bochynska, Ann Sharpe, Brian Toland, Elena Alina Demeter
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引用次数: 0

摘要

许旺病是中枢神经系统内一种罕见的非肿瘤性血管周围异常许旺细胞增生,同时伴有部分轴突髓鞘化。在兽医学领域,仅有一例报告称 3 匹小马和 1 头小牛的脊髓出现了裂隙症。在这里,我们描述了一例 1 天大荷斯坦-弗里斯兰小牛脑部分裂症病例,该病例因关节软化症和过早死亡而提交尸检,未发现其他严重异常。从组织学角度看,大脑延髓白质内和中脑灰质内有多灶性、主要是血管周围的纺锤形细胞增生。这些细胞的免疫标记包括periaxin、髓鞘蛋白0、SOX10和S100,波形蛋白的免疫标记则不明确,表明这些细胞来源于许旺细胞。其他器官未发现任何变化。辅助检查不支持感染病因。在对感染性辅助检测呈阴性的犊牛关节软化症病例进行调查时,应将许旺氏症作为鉴别诊断的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Schwannosis in the brain of a neonatal calf.

Schwannosis is a rare, non-neoplastic, perivascular proliferation of aberrant Schwann cells within the CNS with simultaneous partial myelination of axons. A single report exists in veterinary medicine of schwannosis in the spinal cord of 3 foals and 1 calf. Here we describe a case of schwannosis in the brain of a 1-d-old Holstein-Friesian calf, submitted for autopsy due to arthrogryposis and premature death, with no other gross abnormalities observed. Histologically, the brain had multifocal, mainly perivascular, spindle-cell proliferations within the white matter of the medulla oblongata and focally within the gray matter of the midbrain. These cells immunolabeled with periaxin, myelin protein zero, SOX10, S100, and equivocally for vimentin, indicating Schwann cell origin. No changes were identified within other organs. Ancillary tests did not support an infectious etiology. Schwannosis should be considered as a differential diagnosis when investigating cases of arthrogryposis in calves with negative ancillary tests for infectious conditions.

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来源期刊
CiteScore
3.00
自引率
6.70%
发文量
127
审稿时长
6-16 weeks
期刊介绍: The Journal of Veterinary Diagnostic Investigation (J Vet Diagn Invest) is an international peer-reviewed journal published bimonthly in English by the American Association of Veterinary Laboratory Diagnosticians (AAVLD). JVDI is devoted to all aspects of veterinary laboratory diagnostic science including the major disciplines of anatomic pathology, bacteriology/mycology, clinical pathology, epidemiology, immunology, laboratory information management, molecular biology, parasitology, public health, toxicology, and virology.
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