重度抑郁症患者接受电休克治疗后的急性神经轴重塑：试点研究

Q3 Psychology

Journal of Affective Disorders Reports Pub Date : 2024-09-23 DOI:10.1016/j.jadr.2024.100842

Francesco Bavato , Lena Mehnert , Erich Seifritz , Malek Bajbouj , Simone Grimm , Boris B. Quednow

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引用次数: 0

摘要

电休克疗法（ECT）是治疗重度抑郁症（MDD）的有效方法。神经丝蛋白轻链（NfL）是神经轴突完整性的一种新型血液标记物，在包括重度抑郁症在内的一些精神疾病中会发生改变。先前的研究表明，ECT 对 NfL 水平没有长期影响，但其急性影响尚不明确。因此，我们研究了 13 名 MDD 患者在 19 次单次 ECT 治疗中的血清 NfL 水平。我们发现，ECT后NfL水平出现急性升高（Cohen's d=0.45），这表明轴突出现了短暂的细胞骨架重塑。要确定这些短暂变化是否与治疗反应或认知障碍等副作用相对应，还需要进一步研究。

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Acute neuroaxonal remodelling after electroconvulsive treatment in patients with major depressive disorder: A pilot study

Electroconvulsive therapy (ECT) is an effective treatment for major depressive disorder (MDD). Neurofilament light chain (NfL) is a novel blood marker of neuroaxonal integrity, which is altered in some psychiatric disorders including MDD. Prior studies reported no long-term impact of ECT on NfL levels, but the acute effects are unclear yet. Therefore, we investigated serum NfL levels from 19 single ECT sessions in 13 patients with MDD. We found an acute increase in NfL levels post-ECT (Cohen's d=0.45), suggesting transient cytoskeletal remodelling in axons. Further research is needed to ascertain if these transient changes correspond to treatment response or side effects such as cognitive impairment.

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