自噬及其在胃肠道疾病中的作用。

IF 4.3 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Bo-Zong Shao, Wen-Gang Zhang, Zhen-Yu Liu, En-Qiang Linghu
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引用次数: 0

摘要

胃肠道疾病包括一系列影响消化系统内各种器官的疾病,如食道、胃、结肠、直肠、胰腺、肝脏、小肠和胆管。自噬在胃肠道疾病的病因和进展中的作用已引起了广泛关注。本文旨在通过综合最新研究成果,评估自噬在胃肠道疾病中的影响和机制。具体而言,我们深入研究了与炎症相关的胃肠道疾病,包括溃疡性结肠炎、克罗恩病和胰腺炎,以及胃肠道癌症,如食管癌、胃癌和结肠直肠癌。此外,我们还对 Chang 等人最近在《世界胃肠病学杂志》(World Journal of Gastroenterology)上发表的一篇文章进行了评论。我们的目的是为这些胃肠道疾病的发病机制和治疗方法提供新的视角。本综述旨在通过批判性分析相关出版物,为胃肠道疾病的发病机制和治疗策略提供新的视角。如前所述,自噬在胃肠道疾病中的作用十分复杂,有时甚至存在争议。要充分利用自噬的治疗潜力来治疗这些疾病,必须进行更深入的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autophagy and its role in gastrointestinal diseases.

Gastrointestinal disorders encompass a spectrum of conditions affecting various organs within the digestive system, such as the esophagus, stomach, colon, rectum, pancreas, liver, small intestine, and bile ducts. The role of autophagy in the etiology and progression of gastrointestinal diseases has garnered significant attention. This paper seeks to evaluate the impact and mechanisms of autophagy in gastrointestinal disorders by synthesizing recent research findings. Specifically, we delve into inflammation-related gastrointestinal conditions, including ul-cerative colitis, Crohn's disease, and pancreatitis, as well as gastrointestinal cancers such as esophageal, gastric, and colorectal cancers. Additionally, we provide commentary on a recent publication by Chang et al in the World Journal of Gastroenterology. Our objective is to offer fresh perspectives on the mechanisms and therapeutic approaches for these gastrointestinal ailments. This review aims to offer new perspectives on the mechanisms and therapeutic strategies for gastrointestinal disorders by critically analyzing relevant publications. As discussed, the role of autophagy in gastrointestinal diseases is complex and, at times, contentious. To harness the full therapeutic potential of autophagy in treating these conditions, more in-depth research is imperative.

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来源期刊
World Journal of Gastroenterology
World Journal of Gastroenterology 医学-胃肠肝病学
CiteScore
7.80
自引率
4.70%
发文量
464
审稿时长
2.4 months
期刊介绍: The primary aims of the WJG are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in gastroenterology and hepatology.
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