用于重塑细胞外基质和协同肿瘤免疫疗法的 DC 衍生全细胞细胞因子纳米调节剂。

IF 3.597 Q2 Pharmacology, Toxicology and Pharmaceutics

MedChemComm Pub Date : 2024-09-11 DOI:10.1039/D4MD00496E

Jingsong Lu, Ying Li, Xiaohan Gao, Sumei Chen, Zeping Jin, Xiaoxiao Guo, Wensheng Xie, Zhenhu Guo, Yen Wei and Lingyun Zhao

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引用次数: 0

摘要

一种用于肿瘤细胞因子免疫疗法的智能树突状细胞（DC）衍生全细胞细胞因子（DWC）纳米调节剂应运而生。DWCs 从活化的 DC 培养基中纯化，并以纳米剂型的形式应用。研究发现，TCPs 可通过消除肿瘤组织中的纤连蛋白和 I 型胶原（Col-I）重塑细胞外基质，并抑制癌症相关成纤维细胞（CAFs）中 α-SMA 的表达。此外，在局部 TCP 治疗后，结合放疗可达到显著的肿瘤抑制效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

DC-derived whole cell cytokine nano-regulator for remodelling extracellular matrix and synergizing tumor immunotherapy†

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DC-derived whole cell cytokine nano-regulator for remodelling extracellular matrix and synergizing tumor immunotherapy†

A smart dendritic cell (DC)-derived whole cell cytokine (DWC) nano-regulator of TCPs was developed for tumor cytokine-immunotherapy. The DWCs were purified from activated DC-cultured media and applied as a nano-dosage form. It was found that TCPs could remodel extracellular matrices via the elimination of fibronectin and type I collagen (Col-I) in tumor tissues, as well as the inhibition of α-SMA expression in cancer associated fibroblasts (CAFs). Furthermore, after local TCP treatment, significant tumor inhibition could be achieved combined with radiotherapy.

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来源期刊

MedChemComm BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

2.2 months

期刊介绍： Research and review articles in medicinal chemistry and related drug discovery science; the official journal of the European Federation for Medicinal Chemistry. In 2020, MedChemComm will change its name to RSC Medicinal Chemistry. Issue 12, 2019 will be the last issue as MedChemComm.