血浆中较高的动脉粥样硬化指数与椎管内低血压有关：一项多中心横断面研究。

IF 3 3区医学 Q1 UROLOGY & NEPHROLOGY

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI:10.1080/0886022X.2024.2407885

Yanzhe Peng, Dan Shuai, Yuqi Yang, Yan Ran, Jing Yuan, Yan Zha

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引用次数: 0

摘要

背景：接受维持性血液透析（MHD）的患者在透析过程中经常会出现血压下降，即 "析出内低血压"（IDH）。AIP 与糖尿病和心血管事件等疾病有关。目前仍不清楚 AIP 是否与 IDH 相关。本研究旨在探讨 MHD 患者 AIP 与 IDH 之间的关系：在这项多中心横断面研究中，我们纳入了来自 20 个透析中心的 1946 名成年血液透析患者。根据 AIP 四分位数将患者分为四组。采用线性回归和多元逻辑回归模型分析 AIP 与 IDH 之间的关系。为了评估AIP与IDH之间关系的稳健性，还进一步进行了分组分析：在对潜在的混杂变量进行调整后，AIP每增加1个单位，IDH发生几率就会增加21%。与 Q1 参照组相比，随着 AIP 四分位数的增加，IDH 的几率比（ORs）也逐渐增加（Q2：OR，1.41，95% CI：0.91-2.18；Q3：OR，1.63，95% CI：1.07-2.49；Q4：OR，1.57，95% CI：1.01-2.42）。在按年龄、性别、糖尿病史、心力衰竭和心肌梗死分层的亚组分析中未观察到交互作用：结论：AIP水平升高与MHD患者罹患IDH的风险增加有关。

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Higher atherogenic index of plasma is associated with intradialytic hypotension: a multicenter cross-sectional study.

Background: Patients receiving maintenance hemodialysis (MHD) frequently encounter a drop in blood pressure during dialysis, known as intradialytic hypotension (IDH). The AIP is associated with diseases such as diabetes and cardiovascular events. It remains unclear whether the AIP is associated with IDH. The present study aimed to explore the association between AIP and IDH in MHD patients.

Methods: In this multi-center cross-sectional study, we included 1946 adult hemodialysis patients from twenty dialysis centers. Patients were divided into four groups based on the AIP quartiles. Linear regression and multiple logistic regression models were used to analyze the relationship between AIP and IDH. Subgroup analyses were further conducted to assess the robustness of the association between the AIP and IDH.

Results: After adjusting for potential confounding variables, each 1-unit increase in AIP was associated with a 21% increase in the odds of IDH. The odds ratios (ORs) of IDH increased gradually with higher quartiles of AIP compared with the Q1 reference group (Q2: OR, 1.41, 95% CI: 0.91-2.18; Q3: OR, 1.63, 95% CI: 1.07-2.49; Q4: OR, 1.57, 95% CI: 1.01-2.42). No interaction was observed in the subgroup analysis stratified by age, sex, history of diabetes, heart failure, and myocardial infarction.

Conclusion: Elevated AIP levels are associated with a heightened risk of IDH in MHD patients.

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来源期刊

Renal Failure 医学-泌尿学与肾脏学

CiteScore

3.90

自引率

13.30%

发文量

374

审稿时长

1 months

期刊介绍： Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.