新生儿麻醉的临床前和临床试验：差距和未来方向。

IF 2.1 3区医学 Q2 PEDIATRICS

Pediatric Radiology Pub Date : 2024-10-01 DOI:10.1007/s00247-024-06066-5

Katherine Barton, R Dexter Yellowman, Tara Holm, Forrest Beaulieu, Gabriel Zuckerberg, Kriti Gwal, Bindu N Setty, Emily Janitz, Misun Hwang

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引用次数: 0

摘要

在过去的 30 年中，有关麻醉可能对发育中的大脑造成有害影响的研究文献大幅增加。最初在动物模型（包括啮齿类动物和非人灵长类动物）中发现的一些令人担忧的结果促使我们对人类进行了越来越深入的研究，包括随机对照试验。本综述将简明扼要地概述我们对麻醉和大脑发育的了解：动物研究的背景、我们在人类身上获得的最可靠的结果以及有待完成的工作。这与儿科放射学受众尤其相关，因为我们有独特的机会通过创新来改变成像过程中的麻醉暴露。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pre-clinical and clinical trials for anesthesia in neonates: gaps and future directions.

Literature examining possible deleterious effects of anesthesia exposure on the developing brain has increased substantially over the past 30 years. Initial concerning findings in animal models, both rodents and non-human primates, prompted increasingly thorough examinations in humans, including randomized controlled trials. This review will provide a concise overview of what we know about anesthesia and the developing brain: the background in animal studies, the most robust results we have in humans, and the work yet to be done. This is particularly relevant to a pediatric radiology audience because we have the unique opportunity to modify anesthesia exposure during imaging through innovation.

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来源期刊

Pediatric Radiology 医学-核医学

CiteScore

4.40

自引率

17.40%

发文量

300

审稿时长

3-6 weeks

期刊介绍： Official Journal of the European Society of Pediatric Radiology, the Society for Pediatric Radiology and the Asian and Oceanic Society for Pediatric Radiology Pediatric Radiology informs its readers of new findings and progress in all areas of pediatric imaging and in related fields. This is achieved by a blend of original papers, complemented by reviews that set out the present state of knowledge in a particular area of the specialty or summarize specific topics in which discussion has led to clear conclusions. Advances in technology, methodology, apparatus and auxiliary equipment are presented, and modifications of standard techniques are described. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.