保护生命线隧道纳米管连接神经元和小胶质细胞

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2024-09-25 DOI:10.1016/j.neuron.2024.07.027

Jonas J Neher, Mikael Simons

引用次数: 0

摘要

隧道纳米管（TNTs）可促进细胞间的胞内货物交换。在本期《神经元》（Neuron）杂志上，Scheiblich 等人1揭示了 TNTs 可选择性地介导细胞质蛋白聚集体从神经元向小胶质细胞的双向转移，以及线粒体从小胶质细胞向神经元的双向转移，从而保护神经元的健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Protective lifelines: Tunneling nanotubes connect neurons and microglia.

Tunneling nanotubes (TNTs) facilitate the exchange of intracellular cargo between cells. In this issue of Neuron, Scheiblich et al.¹ reveal that TNTs selectively mediate the bidirectional transfer of cytoplasmic protein aggregates from neurons to microglia and mitochondria from microglia to neurons, thereby preserving neuronal health.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.