抗磷脂综合征和血栓栓塞性疾病中常见 MicroRNAs 表达特征的鉴定:范围综述。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-11-01 Epub Date: 2024-09-27 DOI:10.1177/09612033241286601
Camila de Oliveira Vaz, Bruna Cardoso Jacintho, Gabrielle de Mello Santos, José Diogo de Oliveira, Bruna Moraes Mazetto, Murilo Vieira Geraldo, Fernanda A Orsi
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引用次数: 0

摘要

背景:抗磷脂综合征(APS)是一种获得性自身免疫性疾病,其特点是不同的病理生理机制导致不同的表现,包括静脉和动脉血栓形成。尽管 APS 缺乏血栓形成风险的特异性标志物,但导致 APS 血栓形成的某些机制可能与其他血栓栓塞性疾病的机制重叠。了解这些相似之处对于改进 APS 的血栓形成风险评估非常重要。微小RNA(MiRNA)是调节基因表达的RNA分子,可能会影响自身免疫反应和凝血功能。目的:在这篇范围综述中,我们旨在研究与APS和其他血栓栓塞性疾病相关的共同miRNAs谱,以此确定表明APS患者血栓形成倾向的标志物:miRs-124-3p、125b-5p、125a-5p和17-5p与APS和动脉血栓形成有关,而miRs-106a-5p、146b-5p、15a-5p、222-3p和451a与APS和静脉血栓形成有关。此外,miR-126a-3p 与 APS 以及动脉和静脉血栓都有关联:我们观察到 APS 与非 APS 相关血栓形成有共同的 miRNAs 特征,这表明 miRNA 表达谱可作为 APS 血栓形成风险的标志物。有必要进一步验证 APS 中有利于血栓形成的 miRNA 特征,以改进 APS 的风险评估、诊断和管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of common MicroRNAs expression signatures in antiphospholipid syndrome and thromboembolic disease: A scoping review.

Background: Antiphospholipid syndrome (APS) is an acquired autoimmune disorder characterized by distinct pathophysiological mechanisms leading to heterogeneous manifestations, including venous and arterial thrombosis. Despite the lack of specific markers of thrombosis risk in APS, some of the mechanisms responsible for thrombosis in APS may overlap with those of other thromboembolic diseases. Understanding these similarities is important for improving the assessment of thrombosis risk in APS. MicroRNAs (MiRNAs) are RNA molecules that regulate gene expression and may influence the autoimmune response and coagulation.

Purpose: In this scoping review we aimed to investigate shared miRNAs profiles associated with APS and other thromboembolic diseases as a means of identifying markers indicative of a pro-thrombotic profile among patients with APS.

Data collection and results: Through a comprehensive search of scientific databases, 45 relevant studies were identified out of 1020 references. miRs-124-3p, 125b-5p, 125a-5p, and 17-5p, were associated with APS and arterial thrombosis, while miRs-106a-5p, 146b-5p, 15a-5p, 222-3p, and 451a were associated with APS and venous thrombosis. Additionally, miR-126a-3p was associated with APS and both arterial and venous thrombosis.

Conclusion: We observed that APS shares a common miRNAs signature with non-APS related thrombosis, suggesting that miRNA expression profiles may serve as markers of thrombotic risk in APS. Further validation of a pro-thrombotic miRNA signature in APS is warranted to improve risk assessment, diagnosis, and management of APS.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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