同种双侧肾上腺神经母细胞瘤：病例报告和文献综述。

IF 0.9 4区医学 Q4 HEMATOLOGY

Journal of Pediatric Hematology/Oncology Pub Date : 2024-11-01 Epub Date: 2024-09-30 DOI:10.1097/MPH.0000000000002954

Serena Tropia, Angela Guarina, Giulia Angela Restivo, Fabrizio Di Francesco, Angela Trizzino, Paolo D'Angelo

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引用次数: 0

摘要

一名婴儿在一个多月大时出现右侧肾上腺大肿块、多处肝脏病变和弥漫性骨髓浸润。经过针刺活检，组织学定义为神经母细胞瘤，她接受了化疗和随后的完全切除术。确诊三年后，发现左肾上腺局部有一巨大肿块。患者接受了完整的手术切除，诊断为分化较差的神经母细胞瘤，多处淋巴结受累。患者接受了辅助化疗。据我们所知，这是第一例关于双侧肾上腺神经母细胞瘤基因表达完全不同的病例报告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metachronous Bilateral Adrenal Neuroblastoma: A Case Report and Literature Review.

A baby presented with a large right adrenal mass, multiple hepatic lesions and diffuse bone marrow infiltration when she was just over 1 month old. After needle biopsy and a histologic definition of neuroblastoma, she underwent chemotherapy and a subsequent complete resection. Three years after diagnosis, a large left adrenal localized mass was detected. The patient underwent complete surgical excision, and a diagnosis of poorly differentiated neuroblastoma with multiple lymph nodes involvement was defined. Adjuvant chemotherapy was initiated. To our knowledge, it is the first case report of metachronous bilateral adrenal neuroblastomas harboring completely different genetic expression profiles.

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来源期刊

Journal of Pediatric Hematology/Oncology 医学-小儿科

CiteScore

1.90

自引率

8.30%

发文量

415

审稿时长

2.5 months

期刊介绍： Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.