超越标签外:关于儿童使用氯氮平的系统回顾》。

IF 1.5 4区 医学 Q2 PEDIATRICS
Thales Pimenta de Figueiredo, Igor Ribeiro de Almeida, Filipe Augusto Cursino de Freitas, Caio Hage Chahine Kubrusly, Antônio Marcos Alvim-Soares Júnior, Débora Marques de Miranda
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引用次数: 0

摘要

引言对于青少年的攻击、暴力和冲动行为,绝不能拖延行为管理和控制。氯氮平已被广泛用于青少年和成人精神分裂症患者的暴力和攻击行为控制。然而,有关氯氮平在儿童中应用的数据却很有限,也没有系统性的综述涉及氯氮平在儿童中的应用。目的和方法:为了更好地了解氯氮平作为治疗非精神分裂症的替代药物的使用条件,并评估目前支持儿童处方氯氮平的证据,我们进行了一项系统性综述。该综述遵循了 PRISMA 指南,并在 PROSPERO 中注册,注册号为 CRD42024537707。结果综述发现,所有研究都使用氯氮平治疗外化行为,尤其是攻击行为,并发现氯氮平在治疗具有治疗耐药性的攻击行为儿童方面具有积极的效果。研究还发现,氯氮平在所有病例中的耐受性都很好。不过,这些研究都很有限,而且主要是开放性试验,没有对照组。结论需要进一步开展高质量的研究,为在儿童中使用氯氮平制定准确的指导方针。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Beyond the Off-Label: A Systematic Review of What We Know About Clozapine Use for Children.

Introduction: It is essential not to delay behavior management and control for aggression, violence, and impulsive behavior in young people. Clozapine has been widely used in adolescents and adults to manage violence and aggression in Schizophrenia. However, there are limited data on the use of clozapine in children, and no systematic review has addressed its use in this population. Objective and Methods: To better understand the conditions under which clozapine is used as a therapeutic alternative for nonschizophrenic diagnoses and to assess the current evidence supporting its prescription to children, a systematic review was conducted. The review followed PRISMA guidelines and was registered in PROSPERO under the ID CRD42024537707. Results: The review identified that all the studies used clozapine to address externalizing behavior, particularly aggressive behavior, and found positive outcomes supporting its use for treating children with treatment-resistant aggression. The studies also found that clozapine was well-tolerated in all cases. However, the studies were limited and mainly consisted of open trials without a control group. Conclusion: Further high-quality research is needed to establish precise guidelines for using clozapine in children.

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来源期刊
CiteScore
3.60
自引率
5.30%
发文量
61
审稿时长
>12 weeks
期刊介绍: Journal of Child and Adolescent Psychopharmacology (JCAP) is the premier peer-reviewed journal covering the clinical aspects of treating this patient population with psychotropic medications including side effects and interactions, standard doses, and research on new and existing medications. The Journal includes information on related areas of medical sciences such as advances in developmental pharmacokinetics, developmental neuroscience, metabolism, nutrition, molecular genetics, and more. Journal of Child and Adolescent Psychopharmacology coverage includes: New drugs and treatment strategies including the use of psycho-stimulants, selective serotonin reuptake inhibitors, mood stabilizers, and atypical antipsychotics New developments in the diagnosis and treatment of ADHD, anxiety disorders, schizophrenia, autism spectrum disorders, bipolar disorder, eating disorders, along with other disorders Reports of common and rare Treatment Emergent Adverse Events (TEAEs) including: hyperprolactinemia, galactorrhea, weight gain/loss, metabolic syndrome, dyslipidemia, switching phenomena, sudden death, and the potential increase of suicide. Outcomes research.
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