迁移性自溶体处理减轻了溶酶体损伤。

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2024-12-02 Epub Date: 2024-09-30 DOI:10.1083/jcb.202403195

Takami Sho, Ying Li, Haifeng Jiao, Li Yu

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引用次数: 0

摘要

溶酶体是细胞内降解和再循环的关键，它采用溶酶吞噬和膜修复机制等损伤控制策略来维持功能和细胞稳态。我们的研究揭示了迁移性自溶体处理（MAD），这是一种对溶酶体损伤的反应，细胞通过自溶体外排排出 LAMP1-LC3 阳性结构，需要自噬机制、SNARE 蛋白和细胞迁移。这一机制对减轻溶酶体损伤至关重要，它强调了细胞迁移在溶酶体损伤控制中的作用，并促进了细胞外小囊泡的释放，凸显了细胞迁移、细胞器质量控制和细胞外小囊泡释放之间错综复杂的关系。

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Migratory autolysosome disposal mitigates lysosome damage.

Lysosomes, essential for intracellular degradation and recycling, employ damage-control strategies such as lysophagy and membrane repair mechanisms to maintain functionality and cellular homeostasis. Our study unveils migratory autolysosome disposal (MAD), a response to lysosomal damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring autophagy machinery, SNARE proteins, and cell migration. This mechanism, crucial for mitigating lysosomal damage, underscores the role of cell migration in lysosome damage control and facilitates the release of small extracellular vesicles, highlighting the intricate relationship between cell migration, organelle quality control, and extracellular vesicle release.

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.