测量乳腺癌妇女的静息能量消耗及其准确性。

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition Pub Date : 2024-09-25 DOI:10.1016/j.clnu.2024.09.037

Iolanda Cioffi , Olivia Di Vincenzo , Delia Morlino , Bruna Ramos da Silva , Carla M. Prado , Lidia Santarpia , Luca Scalfi , Mario Giuliano , Carmine De Angelis , Fabrizio Pasanisi , Grazia Arpino , Maurizio Marra

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引用次数: 0

摘要

背景与目的：乳腺癌（BC）常与肥胖、代谢综合征和肌肉疏松症有关。因此，测量或准确估计静息能量消耗（REE）对于满足营养需求、控制体重以及防止营养不足或营养过剩至关重要。我们的目的是测量并比较 BC 妇女与匹配对照组之间的静息能量消耗。此外，我们还对选定配方的预测准确性进行了评估：本次横断面分析纳入了年龄≥18 岁、新诊断为 BC（0-III 期）且体重指数（BMI）≤ 30 kg/m2 的女性。研究人员进行了人体测量、间接热量测定和生物电阻抗分析（BIA）。获得 BC 数据的患者与年龄和 BMI 范围相似的健康女性进行了比较。测量的 REE（mREE）与 15 个预测方程进行了比较。使用 Bland-Altman 分析评估了不同方法之间的一致性：我们纳入了 106 名 BC 妇女（年龄为 49.9 ± 11.1 岁，体重指数为 24.5 ± 2.8 kg/m2）和 75 名对照组妇女。除脂肪质量百分比外，各组之间在年龄、人体测量和 BIA 变量方面均无差异。与对照组相比，BC 患者的 REE 测量值（单独测量或根据去脂体重（FFM）和年龄调整后）较高（分别为 +4.3 % 和 +6.1%）。在 REE 预测方面，大多数选定的方程都低估了 mREE。精确度差异很大，两个马拉方程的一致性最高（73 % 和 74.5 %），Müller 方程的一致性也很高（74 %），但是，一致性范围很宽，表明存在很大的变异性：结论：与对照组相比，早期 BC 妇女的 mREE 值较高，但其临床意义尚不清楚。所选的预测方程中没有一个能对该群体提供准确和精确的 REE 估计值。尽管马拉方程显示出最高的一致性，但仍需进一步研究以评估 REE 的变异性及其对 BC 女性患者的预测。

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Measurement of resting energy expenditure and its accuracy in women with breast cancer

Background & aims

Breast cancer (BC) is frequently linked with obesity, metabolic syndrome, and sarcopenia. Therefore, measuring or accurately estimating resting energy expenditure (REE) is crucial for tailoring nutritional needs, managing weight and prevent under- or over-nutrition. We aimed to measure and compare REE between women with BC and a matched control group. Moreover, the prediction accuracy of selected formulas was evaluated.

Methods

Women aged ≥18 years with newly diagnosis of BC (stage 0-III) and body mass index (BMI) ≤ 30 kg/m² were included in this cross-sectional analysis. Anthropometry, indirect calorimetry, and bioelectrical impedance analysis (BIA) were performed. Patients with BC data were compared to healthy women with similar age and BMI range. Measured REE (mREE) was compared against 15 predictive equations. Agreement between methods was evaluated using Bland-Altman analysis.

Results

We included 106 women with BC (age 49.9 ± 11.1 years and BMI 24.5 ± 2.8 kg/m²) and 75 women as control group. There were no differences in age, anthropometry, and BIA variables between groups, except for percentage fat mass. Measured REE values, alone and adjusted for fat-free mass (FFM) and age, were higher in patients with BC compared to controls (+4.3 % and +6.1 %, respectively). Regarding REE prediction, most of the selected equations underestimated mREE. Precision varied widely, with the two Marra equations showing the highest agreement (73 % and 74.5 %) along with the Müller equation (74 %), however, the wide limit of agreement range indicates substantial variability.

Conclusions

Women with early-stage BC exhibited higher mREE compared to controls, albeit its clinical significance is unknown. None of the selected predictive equations provided accurate and precise REE estimates in this group. Although the Marra equation displayed the highest agreement, further studies are needed to evaluate REE variability and its prediction in women with BC.

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.