在一组中老年人中，凯斯勒心理压力量表（K10）得分越高，血清麦角硫因浓度越低，血清不对称二甲基-L-精氨酸浓度越高。

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2024-09-28 DOI:10.1016/j.clnesp.2024.09.023

Salvatore Sotgia , Arduino A. Mangoni , Stefano Zoroddu , Biagio Di Lorenzo , Angelo Zinellu , Ciriaco Carru , Mark McEvoy

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引用次数: 0

摘要

背景：麦角硫因（ERT）和不对称二甲基-L-精氨酸（ADMA）与老年人的认知能力下降和痴呆症有关，但它们与心理压力之间的相互作用仍未得到研究。本研究旨在测量具有代表性的社区居住老年人血清中 ERT 和 ADMA 的浓度，并确定它们与心理困扰的关系：方法：从猎人社区研究（Hunter Community Study）的澳大利亚老年人（平均年龄为 65.5 ± 7.5 岁）样本中收集了有关临床、生活方式、人口特征以及 ERT 和 ADMA 血清浓度的数据。心理压力采用自我报告的凯斯勒心理压力量表（K10）进行评估：结果：在有心理困扰的人中，血清 ERT 浓度下降了 24%，而 ADMA 浓度上升了 6%。在考虑年龄和性别因素的调整分析中，只有 ERT 仍与心理压力独立相关。ERT每增加一个单位，出现心理困扰的几率就会降低约68%：结论：在老年人中观察到的血清 ERT 浓度随心理压力增加而降低的趋势表明，这种化合物与心理健康之间存在潜在联系。鉴于ERT来源于饮食，其整合提供了治疗机会，值得在干预研究中进行调查。

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查看原文本刊更多论文

Higher scores of the Kessler Psychological Distress Scale (K10) are associated with lower serum ergothioneine and higher serum asymmetric dimethyl-l-arginine concentrations in a cohort of middle-aged and older adults

Background

Ergothioneine (ERT) and asymmetric dimethyl-l-arginine (ADMA) have been associated with cognitive decline and dementia in older adults, but their interplay with psychological distress remains unexplored. This study aimed to measure the serum concentrations of ERT and ADMA in a representative sample of older community-dwelling adults and to determine their association with psychological distress.

Methods

Data on clinical, lifestyle, demographic characteristics, and serum concentrations of ERT and ADMA were collected from a population-based sample of older Australian adults (mean age 65.5 ± 7.5 years) from the Hunter Community Study. Psychological distress was assessed using the self-reported Kessler Psychological Distress Scale (K10).

Results

In individuals with psychological distress, serum ERT concentrations decreased by 24 %, while ADMA concentrations increased by 6 %. In adjusted analysis, accounting for age and sex, only ERT remained independently associated with psychological distress. For each unit increase in ERT, the odds of experiencing psychological distress decreased by approximately 68 %.

Conclusion

The trend of decreasing serum ERT concentrations observed in older adults with increasing psychological distress suggests a potential link between this compound and mental health. Given the dietary origin of ERT, its integration offers therapeutic opportunities that warrant investigation in intervention studies.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.