"尿路感染：从传统检测到新兴技术"。

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2024-09-26 DOI:10.1016/j.cca.2024.119979

Kavi Bharathi Ramaiah , Indhu Suresh , Noel Nesakumar , N. Sai Subramanian , John Bosco Balaguru Rayappan

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引用次数: 0

摘要

尿路感染（UTI）是一个日益严重的全球健康问题，它导致住院人数和抗生素使用量增加，从而助长了抗菌药耐药性的出现。目前的诊断方法耗时长、经济负担大，需要专门的基础设施。要解决这些障碍，就必须开发一种精确的诊断模式，以加快鉴定速度并加强抗生素管理。生物传感器被公认为具有变革性的功效，它的应用是一个很有前景的解决方案。最近，生物传感器技术取得了长足进步，引入了开创性的方法，产生了相关的生物传感器和集成系统，对护理点应用产生了重大影响。这篇综述从历史角度出发，全面阐述了UTI 诊断、疾病病因学和生物标志物方面的进展，强调了这些创新在优化患者护理方面的潜在优势。

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“Urinary tract infection: Conventional testing to developing Technologies”

Urinary tract infections (UTIs) present an escalating global health concern, precipitating increased hospitalizations and antibiotic utilization, thereby fostering the emergence of antimicrobial resistance. Current diagnostic modalities exhibit protracted timelines and substantial financial burdens, necessitating specialized infrastructures. Addressing these impediments mandates the development of a precise diagnostic paradigm to expedite identification and augment antibiotic stewardship. The application of biosensors, recognized for their transformative efficacy, emerges as a promising resolution. Recent strides in biosensor technologies have introduced pioneering methodologies, yielding pertinent biosensors and integrated systems with significant implications for point-of-care applications. This review delves into historical perspectives, furnishing a comprehensive delineation of advancements in UTI diagnostics, disease etiology, and biomarkers, underscoring the potential merits of these innovations for optimizing patient care.

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.