脆弱拟杆菌囊泡对化学药物诱导的大鼠结肠炎模型的治疗作用

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-30 DOI:10.1007/s10517-024-06237-2

O Yu Shagaleeva, D A Kashatnikova, E A Vorobyeva, D A Kardonsky, A S Silantiev, B A Efimov, V A Ivanov, Yu A Bespyatikh, N B Zakharzhevskaya

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引用次数: 0

摘要

研究人员在右旋糖酐硫酸钠诱导的大鼠结肠炎模型中研究了脆弱拟杆菌囊泡的抗炎特性。根据组织学结果，在治疗中添加脆弱拟杆菌囊泡可促进结肠修复。对疾病活动指数的评估证实了结肠的高恢复率：在服用囊泡的背景下，观察到大便无血、大便稠度正常、体重恢复正常。

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Therapeutic Effects of Bacteroides fragilis Vesicles in a Model of Chemically Induced Colitis in Rats.

The anti-inflammatory properties of Bacteroides fragilis vesicles were studied in a rat model of dextran sodium sulfate-induced colitis. According to the histology results, addition of B. fragilis vesicles to the therapy promoted colon repair. Evaluation of the disease activity index confirms the high rate of colon recovery: against the background of vesicle administration, the absence of blood in stool, normal stool consistency, and body weight normalization were observed.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.