通过高架迷宫试验和记录超声波发声比较研究松果菊碱的抗焦虑活性

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-09-01 Epub Date: 2024-09-28 DOI:10.1007/s10517-024-06242-5

Yu V Nesterova, O V Vsyakikh, P V Kul'pin, T N Povetyeva, G N Zyuz'kov, N I Suslov, V V Zhdanov, E A Losev

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引用次数: 0

摘要

研究发现，按25微克/千克的剂量给小鼠口服二萜生物碱松果菊碱，可在高架加迷宫测试中产生明显的抗焦虑效果，与苯二氮杂卓类抗焦虑药物苯西泮的效果相当。对动物超声波发声的记录显示，在松果菊碱和参比药物的作用下，短高频（50 kHz）信号的数量有所增加，这证实了它们的抗焦虑特性。

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Comparative Study of the Anxiolytic Activity of Songorine in Elevated Plus Maze Test and by Recording Ultrasonic Vocalizations.

It was found that the diterpene alkaloid songorine administered per os to mice at a dose of 25 μg/kg provides a pronounced anxiolytic effect during elevated plus maze testing comparable to the effect of the benzodiazepine anxiolytic phenazepam. Recording of ultrasonic vocalizations of animals revealed an increase in the number of short high-frequency (50 kHz) signals under the action of songorine and the reference drug, which confirms their anti-anxiety properties.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.