肝细胞癌免疫检查点疗法的进展。

IF 1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Yamei Huang, Weiping Yu
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引用次数: 0

摘要

肝细胞癌(HCC)的发病率和致死率逐年上升,而传统疗法已被证明对晚期患者无效。近年来,免疫检查点疗法迅速发展,在多种癌症中取得了可喜的成果,为癌症治疗带来了新的希望。然而,免疫检查点疗法对 HCC 的疗效因人而异,只有一小部分 HCC 患者能产生积极反应。造成 HCC 患者免疫耐受和疗效不佳的一个主要原因是免疫逃避,这通常是由于免疫细胞浸润不足造成的。了解免疫逃避的内在机制对于提高免疫疗法的疗效至关重要。在这篇综述中,我们旨在总结在免疫检查点疗法中观察到的免疫逃避机制,并讨论这种治疗方法的未来发展方向。我们的目标是提供有助于克服免疫逃避的见解,从而提高免疫疗法的疗效并延长患者的生存时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in Immune Checkpoint Therapy in Hepatocellular Carcinoma.

The incidence and lethality of hepatocellular carcinoma (HCC) are increasing annually, and traditional treatments have been proven to be ineffective for patients with advanced stages of the disease. In recent years, immune checkpoint therapy has rapidly evolved, demonstrating promising results across a wide range of cancers and offering new hope for cancer treatment. However, the efficacy of immune checkpoint therapy in HCC varies greatly among individuals, with only a small proportion of HCC patients responding positively. A major cause of immune resistance and poor efficacy in HCC patients is immune evasion, which is often due to insufficient infiltration of immune cells. Understanding the mechanisms underlying immune evasion is crucial for enhancing the efficacy of immune therapies. In this review, we aim to summarize the mechanisms of immune evasion observed during immune checkpoint therapy and discuss future directions for this therapeutic approach. Our goal is to provide insights that could help overcome immune evasion, thereby improving the efficacy of immune therapies and extending patient survival time.

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来源期刊
British journal of hospital medicine
British journal of hospital medicine 医学-医学:内科
CiteScore
1.50
自引率
0.00%
发文量
176
审稿时长
4-8 weeks
期刊介绍: British Journal of Hospital Medicine was established in 1966, and is still true to its origins: a monthly, peer-reviewed, multidisciplinary review journal for hospital doctors and doctors in training. The journal publishes an authoritative mix of clinical reviews, education and training updates, quality improvement projects and case reports, and book reviews from recognized leaders in the profession. The Core Training for Doctors section provides clinical information in an easily accessible format for doctors in training. British Journal of Hospital Medicine is an invaluable resource for hospital doctors at all stages of their career. The journal is indexed on Medline, CINAHL, the Sociedad Iberoamericana de Información Científica and Scopus.
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