季节和遗传对大西洋鲑幼鱼脂质特征的影响。

IF 3.9 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Andrew H. House , Paul V. Debes , Minna Holopainen , Reijo Käkelä , Iikki Donner , Morgane Frapin , Ehsan Pashay Ahi , Johanna Kurko , Hanna Ruhanen , Craig R. Primmer
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引用次数: 0

摘要

季节性会影响许多生理特征,这些特征需要最佳的能量能力来完成生命阶段的转换。在大西洋鲑鱼中,高能量状态对于启动成熟至关重要。早期的研究已将编码 vgll3 的基因组区域与成熟年龄联系起来,这可能是通过身体状况介导的。Vgll3 还被证明是小鼠脂肪生成的抑制剂。在此,我们研究了与早熟(EE)和晚熟(LL)相关的季节和 vgll3 基因型对大西洋鲑幼鱼肌肉和肝脏脂质特征的影响。我们从大西洋鲑受精开始饲养了两年,并在第二年的春季和秋季对其肌肉和肝脏取样(此时部分雄性大西洋鲑已性成熟)。我们发现,未成熟雄性和雌性鲑鱼的肌肉脂质特征没有季节或基因型的影响。然而,在肝脏中,我们检测到三酰甘油富集以及膜脂质、磷脂酰胆碱和磷脂酰乙醇胺从春季到秋季的特定基因型变化方向。具体来说,从春季到秋季,vgll3*EE个体的膜脂浓度增加,而vgll3*LL个体的膜脂浓度降低。这可能是由于:1)与 vgll3*LL 基因型个体相比,vgll3*EE 基因型个体的内质网(ER)功能在季节性上更加稳定;或 2)与 vgll3*EE 基因型个体相比,vgll3*LL 基因型个体从春到秋在肝脏中储存的脂滴更大,但却牺牲了ER的能力。膜脂浓度的这种基因型特异性季节变化方向为 vgll3 与脂质代谢和储存的潜在联系机制提供了更多间接证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seasonal and genetic effects on lipid profiles of juvenile Atlantic salmon
Seasonality can influence many physiological traits requiring optimal energetic capacity for life-history stage transitions. In Atlantic salmon, high-energy status is essential for the initiation of maturation. Earlier studies have linked a genomic region encoding vgll3 to maturation age, potentially mediated via body condition. Vgll3 has also been shown to act as an inhibitor of adipogenesis in mice. Here we investigate the influence of season and vgll3 genotypes associating with early (EE) and late (LL) maturation on lipid profiles in the muscle and liver of juvenile Atlantic salmon. We reared Atlantic salmon for two years from fertilization and sampled muscle and liver during the spring and autumn of the second year (at which time some males were sexually mature). We found no seasonal or genotype effect in the muscle lipid profiles of immature males or females. However, in the liver we detected a triacylglycerol enrichment and a genotype specific direction of change in membrane lipids, phosphatidylcholine and phosphatidylethanolamine, from spring to autumn. Specifically, from spring to autumn membrane lipid concentrations increased in vgll3*EE individuals but decreased in vgll3*LL individuals. This could be explained by 1) a seasonally more stable capacity of endoplasmic reticulum (ER) functions in vgll3*EE individuals compared to vgll3*LL individuals or 2) vgll3*LL individuals storing larger lipid droplets from spring to autumn in the liver compared to vgll3*EE individuals at the expense of ER capacity. This genotype specific seasonal direction of change in membrane lipid concentrations provides more indirect evidence of a potential mechanism linking vgll3 with lipid metabolism and storage.
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来源期刊
CiteScore
11.00
自引率
2.10%
发文量
109
审稿时长
53 days
期刊介绍: BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.
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