睾丸纤维化的病理、诊断、发病机制和治疗：相关疾病透视。

IF 3.2 2区医学 Q1 ANDROLOGY

Andrology Pub Date : 2024-09-27 DOI:10.1111/andr.13769

Ying Xu, Poyi Hu, Wanyi Chen, Jin Chen, Chunyan Liu, Huiping Zhang

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引用次数: 0

摘要

睾丸纤维化是一种慢性进行性疾病，其特点是细胞外基质蛋白过度沉积。这一过程会导致纤维化重塑、睾丸组织受损以及男性生殖功能不可逆转的丧失。然而，目前还缺乏全面的综述，从不同相关疾病的角度系统地阐明睾丸纤维化的病理、诊断、发病机制和治疗。本综述探讨了睾丸纤维化的这些方面，尤其侧重于阐明睾丸细胞的内在机制。它为未来的研究和临床干预提供了相关的见解。

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Testicular fibrosis pathology, diagnosis, pathogenesis, and treatment: A perspective on related diseases.

Testicular fibrosis is a chronic and progressive condition characterized by the excessive deposition of extracellular matrix proteins. This process leads to fibrotic remodeling, damage to testicular tissue, and the irreversible loss of male reproductive function. However, there is currently a lack of comprehensive reviews systematically elucidating the pathology, diagnosis, pathogenesis, and treatment of testicular fibrosis from the perspectives of different related diseases. This review addresses these aspects of testicular fibrosis, with a particular emphasis on elucidating the underlying mechanisms of testicular cells. It provides insights that can be relevant for future research and clinical interventions.

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来源期刊

Andrology ANDROLOGY-

CiteScore

9.10

自引率

6.70%

发文量

200

期刊介绍： Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology