摄入质子泵抑制剂与早期慢性淋巴细胞白血病首次治疗时间缩短有关。

IF 1.7 4区医学 Q3 HEMATOLOGY

Acta Haematologica Pub Date : 2024-09-30 DOI:10.1159/000541453

Tamar Tadmor, Guy Melamed, Hilel Alapi, Sivan Gazit, Tal Patalon, Lior Rokach

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引用次数: 0

摘要

质子泵抑制剂（PPIs）是全球使用最广泛的药物之一(1)。使用质子泵抑制剂已成为一种普遍做法，并被过度用于所有癌症患者，包括血液恶性肿瘤患者。在当前的研究中，我们旨在回顾性地探讨 PPI 对接受观察和等待治疗的大量慢性淋巴细胞白血病患者首次治疗时间（TTFT）的影响。我们的队列包括 3474 名治疗无效的慢性淋巴细胞白血病患者，中位随访时间为 1745 天（602-3700 天）。1061名患者（30.5%）在观察和等待期间接受了至少3个月的PPI治疗。研究发现，服用 PPI 与较短的 TTFT 有关：在服用 PPI 的患者中，十年无治疗率为 79.2%，而在未服用 PPI 的患者中，十年无治疗率为 90.6%。总之，CLL 患者常规使用 PPI 可能会对其临床疗程产生负面影响。这一主要观察结果的生物学意义还需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Intake of Proton Pump Inhibitors Is Associated with a Shorter Time to First Treatment in Early-Stage Chronic Lymphocytic Leukemia.

Introduction: Proton pump inhibitors (PPIs) are one of the most widely used drugs worldwide [Gut Liver. 2017;11(1):27-37]. The use of PPI has become a common practice and is overprescribed for all patients with cancer including patients with hematological malignancies. In the current study, we aimed to explore retrospectively the effect of PPI, on time to first treatment (TTFT) in a large cohort of patients with chronic lymphocytic leukemia (CLL) who were under watch-and-wait approach.

Methods: The cohort is based on anonymized data obtained from electronic medical records of Maccabi Healthcare Services (MHS) members, who is the second-largest healthcare organization in Israel, with 2.5 million insured patients, and received a diagnosis of CLL during this period.

Results: Our cohort included 3,474 patients with CLL who are treatment-naïve, and the median follow-up was 1,745 days (602-3,700). A total of 1,061 patients (30.5%) received a PPI agent, for a minimum of 3 months during the watch-and-wait period. The intake of PPI was found to be associated with a shorter TTFT: among PPI users, the 10-year treatment-free ratio is 79.2%, while among non-PPI users it is 90.6%.

Conclusion: Routine use of PPI in CLL patients may negatively impact their clinical course. Biology of this primary observation requires further investigation.

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来源期刊

Acta Haematologica 医学-血液学

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Acta Haematologica'' is a well-established and internationally recognized clinically-oriented journal featuring balanced, wide-ranging coverage of current hematology research. A wealth of information on such problems as anemia, leukemia, lymphoma, multiple myeloma, hereditary disorders, blood coagulation, growth factors, hematopoiesis and differentiation is contained in first-rate basic and clinical papers some of which are accompanied by editorial comments by eminent experts. These are supplemented by short state-of-the-art communications, reviews and correspondence as well as occasional special issues devoted to ‘hot topics’ in hematology. These will keep the practicing hematologist well informed of the new developments in the field.