血管内治疗未破裂颅内动脉瘤后造影剂诱发神经毒性的发生率:一项单中心队列研究。

IF 2 4区 医学 Q3 CLINICAL NEUROLOGY
Frederick P. Mariajoseph, Leon T. Lai, Justin Moore, Ronil V. Chandra, Tony Goldschlager, Adrian Praeger, Daniel Yu, Lee-Anne Slater
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引用次数: 0

摘要

背景:造影剂诱导的神经毒性(CIN)是公认的血管内介入手术并发症,近年来已被越来越多地观察到。在其他临床缺陷中,CIN 的确切发生率尚不清楚,尤其是在颅内介入手术后:方法:对接受选择性血管内治疗未破裂颅内动脉瘤(UIAs)的连续患者进行了一项回顾性研究。曾有动脉瘤破裂的患者被排除在外。这项研究的主要目的是确定血管内 UIA 治疗后 CIN 的发生率。我们的次要目的是分离出发生 CIN 的潜在预测因素:从 2017 年到 2023 年,共有 158 名患者接受了血管内 UIA 治疗,中位年龄为 64 岁(IQR:54-72),女性占 70.3%。在研究期间,CIN 的粗发病率为 2.5%(95% CI:0.7 - 6.4%)。CIN 最常见的临床表现是意识模糊(75%)和癫痫发作(50%)。研究人员进行了统计分析,发现手术时间延长与 CIN 的发生显著相关(OR 12.55; p = 0.030):临床医生应意识到血管内神经介入术后发生 CIN 的风险,尤其是技术难度高、手术时间长的病例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Incidence of contrast-induced neurotoxicity following endovascular treatment of unruptured intracranial aneurysms: a single-centre cohort study

Background

Contrast-induced neurotoxicity (CIN) is a recognised complication of endovascular procedures and has been increasingly observed in recent years. Amongst other clinical gaps, the precise incidence of CIN is unclear, particularly following intracranial interventional procedures.

Methods

A retrospective study of consecutive patients undergoing elective endovascular treatment of unruptured intracranial aneurysms (UIAs) was performed. Patients with previously ruptured aneurysms were excluded. The primary aim of this study was to determine the incidence of CIN following endovascular UIA treatment. Our secondary aim was to isolate potential predictive factors for developing CIN.

Results

From 2017 to 2023, a total of 158 patients underwent endovascular UIA treatment, with a median age of 64 years (IQR: 54–72), and 70.3% of female sex. Over the study period, the crude incidence of CIN was 2.5% (95% CI: 0.7 – 6.4%). The most common clinical manifestation of CIN was confusion (75%) and seizures (50%). Statistical analysis was conducted, and prolonged procedural duration was found be significantly associated with developing CIN (OR 12.55; p = 0.030).

Conclusion

Clinicians should be aware of the risk of CIN following endovascular neurointervention, particularly following technically challenging cases resulting in prolonged procedural time.

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来源期刊
Acta neurologica Belgica
Acta neurologica Belgica 医学-临床神经学
CiteScore
4.20
自引率
3.70%
发文量
300
审稿时长
6-12 weeks
期刊介绍: Peer-reviewed and published quarterly, Acta Neurologica Belgicapresents original articles in the clinical and basic neurosciences, and also reports the proceedings and the abstracts of the scientific meetings of the different partner societies. The contents include commentaries, editorials, review articles, case reports, neuro-images of interest, book reviews and letters to the editor. Acta Neurologica Belgica is the official journal of the following national societies: Belgian Neurological Society Belgian Society for Neuroscience Belgian Society of Clinical Neurophysiology Belgian Pediatric Neurology Society Belgian Study Group of Multiple Sclerosis Belgian Stroke Council Belgian Headache Society Belgian Study Group of Neuropathology
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