Organocatalytic enantioselective assembly of dispiro-bisoxindoles with vicinal stereocenters

Notwithstanding the rapid development achieved in enantioselective transformations, accessing contiguous quaternary and tertiary stereocenters ubiquitous in natural products and biologically active compounds has been an important and challenging task for synthetic chemists in modern organic chemistry. Drawing inspiration from the huge significance of spirooxindoles featuring a unique spatial structure and incredible medicinal activities, the search for these fascinating compounds in nature and developing new synthetic routes for installing multiple stereocenters remain core areas for synthetic chemists. This mini-review article demonstrates a transitory overview of the organocatalytic enantioselective strategies developed for assembling broad-spectrum dispiro-bisoxindole scaffolds comprising vicinal quaternary and tertiary stereocenters. While addressing the notable advancement accomplished in this intriguing field, we have also discussed the drawbacks and challenges associated with the reaction findings to support more research.