分次二氧化碳激光联合外用他克莫司治疗慢性脱发：病例系列研究。

IF 3.2 3区生物学 Q1 BIOLOGY

Life-Basel Pub Date : 2024-09-07 DOI:10.3390/life14091128

Giulio Rizzetto, Edoardo De Simoni, Helena Gioacchini, Elisa Molinelli, Annamaria Offidani, Oriana Simonetti

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引用次数: 0

摘要

斑秃（AA）是一种非瘢痕性自身免疫性疾病，需要长期治疗。局部、鞘内或全身使用皮质类固醇激素是首选疗法。然而，考虑到皮肤萎缩的风险和可能缺乏临床反应，迫切需要新的治疗方案。点阵二氧化碳激光（FCL）已被证明单独使用或与其他药物联合使用有效。然而，还没有研究评估过 FCL 与外用他克莫司之间的关联。我们报告了三例对皮质类固醇激素耐药至少 12 个月的 AA 病例，他们接受了外用他克莫司 0.1% 软膏和 FCL 对部分斑块的治疗。治疗开始 16 周后，所有患者联合治疗部位的临床和三镜检查指标均有所改善。FCL 和他克莫司可能是一种新的治疗选择，但还需要进一步的研究来证实。

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Fractionated CO₂ Laser in Combination with Topical Tacrolimus for Chronic Alopecia Areata: A Case Series Study.

Alopecia areata (AA) is a non-scarring autoimmune disease requiring long-term treatments. Topical, intralesional or systemic corticosteroids are the first option. However, considering the risk of skin atrophy and the possible lack of clinical response, new treatment options are urgently needed. A fractional carbon dioxide laser (FCL) has been proven to be effective alone or in combination with other drugs. However, no study has ever evaluated the association between FCL and topical tacrolimus. We report three cases of AA resistant to corticosteroids for at least 12 months, treated with topical tacrolimus 0.1% ointment and FCL on some patches. After 16 weeks from the beginning of treatment, all patients showed improvement in clinical and trichoscopic parameters in the areas treated in combination. FCL and tacrolimus may represent a new therapeutic option, but further studies are needed for confirmation.

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来源期刊

Life-Basel Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

4.30

自引率

6.20%

发文量

1798

审稿时长

11 weeks

期刊介绍： Life (ISSN 2075-1729) is an international, peer-reviewed open access journal of scientific studies related to fundamental themes in Life Sciences, especially those concerned with the origins of life and evolution of biosystems. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers.