来自稀有放线菌 Saccharothrix sp. 16Sb2-4 的两种新型 16 元大环内酯--Aldgamycins Q1 和 Q2。

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2024-09-25 DOI:10.1038/s41429-024-00775-7

Keke Luo, Qin Yang, Yuyu Liu, Chenghang Sun, Shaowei Liu

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引用次数: 0

摘要

从稀有放线菌 Saccharothrix sp. 16Sb2-4 的培养液中分离出两种新型 16 元大环内酯，分别命名为阿加霉素 Q1 (1) 和 Q2 (2)。化合物 1 和 2 对粪肠球菌、枯草芽孢杆菌、金黄色葡萄球菌和鲍曼不动杆菌具有中等至弱的抗菌活性，MIC 值为 16 至 64 μg mL-1。

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Aldgamycins Q1 and Q2, two novel 16-membered macrolides from the rare actinomycete Saccharothrix sp. 16Sb2-4

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Aldgamycins Q1 and Q2, two novel 16-membered macrolides from the rare actinomycete Saccharothrix sp. 16Sb2-4

Two novel 16-membered macrolides, named aldgamycin Q1 (1) and Q2 (2), were isolated from the culture broth of the rare actinomycete Saccharothrix sp. 16Sb2-4. The structures of 1 and 2 were elucidated as new aldgamycin analogs with a demethylated mycinose residue by spectroscopic analyses and comparison with data of aldgamycin K. Compounds 1 and 2 showed moderate to weak antibacterial activities against Enterococcus faecalis, Bacillus subtilis, Staphylococcus aureus and Acinetobacter baumannii, with MIC values ranging from 16 to 64 μg mL−1.

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.