星形胶质细胞是脑转移的助推器

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2024-09-30 DOI:10.1038/s41556-024-01516-6

Livia Garzia

引用次数: 0

摘要

原发性癌症的循环肿瘤细胞可能会进入大脑并形成转移。在脑实质中，肿瘤细胞会与驻留的星形胶质细胞、小胶质细胞和神经元产生广泛的相互作用，形成一个肿瘤细胞可以生长的 "生态位"。一项新的研究揭示了一种以前未知的星形胶质细胞-肿瘤细胞相互作用类型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Astrocytes are enablers of brain metastases

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Astrocytes are enablers of brain metastases

Circulating tumour cells from primary carcinomas may reach the brain and establish metastases. In the brain parenchyma, tumour cells initiate extensive interactions with resident astrocytes, microglia and neurons, forming a niche where tumour cells can thrive. A new study reveals a previously unknown type of astrocyte–tumour cell interaction.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology