关于在兔气管中植入不同类型金属支架后并发症的研究

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-13 DOI:10.1016/j.ijporl.2024.112111

Zhenyu Yang , Ziyi Liu , Jie Zhang , Xiaoxiao Li , Daxiong Zeng , Chuanyong Mu , Junhong Jiang

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引用次数: 0

摘要

方法将79只家兔随机分为4组，分别植入定制的镍钛合金金属支架（全覆盖金属支架A组、裸金属支架B组、分段覆盖金属支架C组和对照组D组）。通过观察死亡家兔的解剖和病理标本，比较不同类型金属支架的并发症（气管变形、肉芽组织增生、瘢痕增生和分泌物潴留）；通过检测死亡家兔的气管组织，比较不同类型金属支架的炎症因子表达。A组气管变形、瘢痕增生和分泌物滞留的发生率明显高于B组（P＜0.0167），但A组肉芽组织增生的发生率明显低于B组（P＜0.0167）。A 组瘢痕增生的发生率明显低于 C 组（p < 0.0167），两组在其他并发症方面无明显差异（p > 0.0167）。B组气管变形、瘢痕增生和分泌物潴留的发生率明显低于C组（p < 0.0167），但B组肉芽组织增生的发生率明显高于C组（p < 0.0167）。(结论 (1)全覆盖金属支架、裸金属支架和分段覆盖金属支架的并发症有显著差异；分段覆盖金属支架和全覆盖金属支架的并发症发生率相似。(2)全覆盖金属支架和裸金属支架之间可以观察到不同炎症因子的变化。

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Study on the complications after implantation of different types of metal stents in rabbit trachea

Objective

To observe the complications and inflammatory responses caused by the different types of metal stents in the trachea of rabbits.

Method

79 rabbits were randomly divided into 4 groups and were implanted with the customized nickel-titanium alloy metal stents(fully covered metal stent: group A, bare metal stent: group B, segmented covered metal stent: group C and control group: group D). The complications (tracheal deformation, granulation tissue hyperplasia, scar hyperplasia and secretion retention) of different types of metal stents were compared by observing the anatomical and pathological specimens of dead rabbits; And the expression of inflammatory factors of different types of metal stents were compared by detecting the tissue of tracheas of dead rabbits.

Results

(1)There were significant differences in the above four complications among groups A, B and C(p < 0.01). The incidences of tracheal deformation, scar hyperplasia and secretion retention in group A were significantly higher than that in group B(p < 0.0167), however, the incidence of granulation tissue hyperplasia in group A was significantly lower than that in group B(p < 0.0167). The incidence of scar hyperplasia in group A was significantly lower than that in group C(p < 0.0167) and there were no significant differences in other complications between these two groups(p > 0.0167). The incidences of tracheal deformation, scar hyperplasia and secretion retention in group B were significantly lower than that in group C(p < 0.0167), however, the incidence of granulation tissue hyperplasia in group B was significantly higher than that in group C(p < 0.0167). (2)The concentration of IL-1β in group A was higher than that in group B (p < 0.05 and foldchange>1.2).

Conclusion

(1)There are significant differences in complications between the fully covered metal stent, bare metal stent and segmented covered metal stent; the incidences of complications between the segmented covered metal stent and fully covered metal stent are similar. (2)Changes in different inflammatory factors can be observed between the fully covered and bare metal stent.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.