Mof-mediated paper-based (bio)sensors for detecting of food and environmental pollutants: Preparation strategies and emerging applications

The issue of food safety, which is intricately related to the economic progress of the food industry and public health, has emerged as a significant global concern that is receiving increasing attention worldwide. The implementation of efficient detection technologies plays a vital role in ensuring the safety of food products. In recent years, there has been significant advancement in the progress of POCT (point-of-care testing) biosensors, driven by the increasing demand for rapid and home testing. Paper-based biosensors have emerged as a prominent category within the realm of POCT biosensors, primarily because of their cost-effectiveness, simplicity, and portability. In order to address the growing need for POCT in a variety of applications, there is a highly demanded for the functionalization of paper substrates. Metal-organic framework (MOF), a versatile porous nanomaterial, is presented in the fabrication of paper-derived platforms, meaningfully boosting the detecting feature and application potential. This study offers an overview of the latest developments and emerging trends in MOF-functionalized paper-based biosensors (MOF@paper), encompassing various kinds of substrates, construction techniques, diagnosis applications and mechanisms. Due to the superior performance and multifunctionality of MOF@paper biosensors, this area shows promising prospects in scientific research, food safety, and control applications.