文献中对自噬体-溶酶体/液泡融合模型的说明是否正确?

Yongheng Liang
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引用次数: 0

摘要

过去几十年来,对不同物种自噬的探索已成为细胞生物学的一个热点。大自噬(以下简称 "自噬")是研究最为广泛的一种类型。自噬的特征之一是封闭的双膜成熟自噬体(AP)的外膜(OM)与溶酶体/泡单膜融合。自噬领域的大多数研究人员都同意这一描述。然而,不符合这一描述的 AP-溶酶体/液泡融合模型经常出现在文献中,甚至至今还发表在一些著名期刊上。其中一些被歪曲的模型来自拥有辉煌发表记录的自噬实验室。这些缺陷应作为自噬领域的公告予以解决,以避免传播错误信息。编辑和审稿人是确保模型正确的守护者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Were the autophagosome-lysosome/vacuole fusion models illustrated correctly in the literature?

Exploration of autophagy in different species has become a hotspot in cell biology in the past decades. Macroautophagy (hereafter, autophagy) is the most widely studied type. One of the hallmarks of autophagy is the fusion of the outer membrane (OM) of a closed double-membrane mature autophagosome (AP) with the lysosomal/vacuolar single membrane. Most researchers in the autophagy field agree upon this description. However, AP-lysosome/vacuole fusion models that do not follow this description frequently appear in the literature, even published in some prestigious journals until now. Some of the misrepresented models are from autophagy laboratories with brilliant publication records. These flaws should be addressed as a public announcement in the autophagy field to avoid spreading misinformation. The editors and reviewers are the guardians to ensure correct models.Abbreviations: AP: autophagosome; IM: inner membrane; OM: outer membrane.

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