摄入咖啡会导致易感妊娠大鼠出现类似先兆子痫的综合征。

IF 2.4 Q3 NUTRITION & DIETETICS
Journal of Nutritional Science Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI:10.1017/jns.2024.36
Linyan Chen, Yi Duan, Pan Wang
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引用次数: 0

摘要

咖啡是世界上最受欢迎的饮料之一,人们越来越关注孕期饮用咖啡对健康的危害。子痫前期(PE)是一种严重的妊娠疾病,会导致孕妇血压升高和蛋白尿,胎儿也会因胎盘血管发育不良而生长受限。我们的研究旨在调查妊娠期摄入咖啡对大鼠潜在的潜在血管疾病可能产生的影响。我们使用高剂量(125 毫克/千克/天)的内皮一氧化氮合酶抑制剂 N(γ)-硝基-L-精氨酸甲酯(L-NAME)诱导妊娠大鼠发生 PE,妊娠大鼠作为阳性对照组。此外,还使用低剂量 L-NAME(10 毫克/千克/天)来模拟妊娠大鼠受损的胎盘血管功能。在妊娠 10.5-18.5 天期间,给妊娠大鼠服用咖啡和低剂量 L-NAME。结果显示,服用低剂量 L-NAME + 咖啡的妊娠大鼠会出现 PE 症状,如明显的胎儿生长受限、高血压和蛋白尿,而单独服用低剂量 L-NAME 的妊娠大鼠则不会出现 PE 症状。因此,我们的研究结果表明,孕期摄入咖啡可能会增加易感妇女患 PE 的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Coffee intake leads to preeclampsia-like syndromes in susceptible pregnant rats.

Coffee is one of the most popular beverages worldwide, and there is an increasing concern of the health risk of coffee consumption in pregnancy. Preeclampsia (PE) is a serious pregnancy disease that causes elevated blood pressure and proteinuria in pregnant women and growth restriction of fetuses due to poorly developed placental vasculature. The aim of our study is to investigate the possible effect of coffee intake during pregnancy in rats with potential underlying vasculature conditions. The endothelial nitric oxide synthase inhibitor N(gamma)-nitro-L-arginine methyl ester (L-NAME) at a high dose (125 mg/kg/d) was used to induce PE in pregnant rats, which were used as the positive control group. In addition, low-dose L-NAME (10 mg/kg/d) was used to simulate the compromised placental vasculature function in pregnant rats. Coffee was given together with low-dose L-NAME to the pregnant rats from gestational day 10.5-18.5. Our results show that the pregnant rats treated with low-dose L-NAME + coffee, but not low-dose L-NAME alone, developed PE symptoms such as prominent fetal growth restriction, hypertension, and proteinuria. Therefore, our findings suggest that coffee intake during pregnancy may cause an increased risk of PE in susceptible women.

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来源期刊
Journal of Nutritional Science
Journal of Nutritional Science NUTRITION & DIETETICS-
CiteScore
3.00
自引率
0.00%
发文量
91
审稿时长
7 weeks
期刊介绍: Journal of Nutritional Science is an international, peer-reviewed, online only, open access journal that welcomes high-quality research articles in all aspects of nutrition. The underlying aim of all work should be, as far as possible, to develop nutritional concepts. JNS encompasses the full spectrum of nutritional science including public health nutrition, epidemiology, dietary surveys, nutritional requirements, metabolic studies, body composition, energetics, appetite, obesity, ageing, endocrinology, immunology, neuroscience, microbiology, genetics, molecular and cellular biology and nutrigenomics. JNS welcomes Primary Research Papers, Brief Reports, Review Articles, Systematic Reviews, Workshop Reports, Letters to the Editor and Obituaries.
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