S Grazzini, R Terribili, E Conticini, S Bartalini, L Cantarini, B Frediani
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引用次数: 0
摘要
我们描述了一例因接触二氧化硅粉尘而继发尘肺病的 73 岁男性病例,他被诊断出患有抗中性粒细胞胞浆抗体(ANCA)阳性的显微镜下多血管炎(MPA)相关性颈髓炎。据报道,尘肺病会诱发自身抗体的产生和各种自身免疫性疾病的发病,包括 ANCA 相关性血管炎(AAV)。MPA 是一种小血管的 AAV,通常会影响神经系统,但脊髓炎形式的脊髓受累只是传闻。我们的经验表明,如果尘肺病患者出现与AAV一致的神经系统症状,则应考虑进行自身免疫检查。
Cervical myelopathy as an atypical presentation of antineutrophil cytoplasmic antibody-associated vasculitis in a patient affected by silicosis: a case report and literature overview.
We describe the case of a 73-year-old man affected by pneumoconiosis, secondary to silica dust exposure, who was diagnosed with antineutrophil cytoplasmic antibody (ANCA)-positive microscopic polyangiitis (MPA)-related cervical myelitis. Pneumoconiosis is reported to trigger autoantibody production and the onset of different autoimmune diseases, including ANCA-associated vasculitis (AAV). MPA is an AAV of the small vessels that can often affect the nervous system, although involvement of the spinal cord in the form of myelitis is described as an anecdotal occurrence. Our experience suggests that an autoimmunity workup should be considered for patients with pneumoconiosis who present with neurological symptoms consistent with AAV.
期刊介绍:
Reumatismo is the official Journal of the Italian Society of Rheumatology (SIR). It publishes Abstracts and Proceedings of Italian Congresses and original papers concerning rheumatology. Reumatismo is published quarterly and is sent free of charge to the Members of the SIR who regularly pay the annual fee. Those who are not Members of the SIR as well as Corporations and Institutions may also subscribe to the Journal.