在先兆子痫中表现出差异表达的三个转座元件与增强子区域重叠。

IF 3 2区医学 Q2 DEVELOPMENTAL BIOLOGY

Placenta Pub Date : 2024-09-14 DOI:10.1016/j.placenta.2024.09.010

Laura M. Keighley , Chiemi F. Lynch-Sutherland , Lorissa McDougall , Suzan N. Almomani , Peter Stockwell , Michael R. Eccles , Erin C. Macaulay

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引用次数: 0

摘要

可转座元件（TE）在胎盘发育和功能障碍中起着至关重要的作用。我们的研究利用 RNA-seq 数据集研究了子痫前期（PE）中 TE 的表达。我们确定了差异表达的 TEs，并探索了最重要 TEs 的基因组位置，研究了它们可能的调控作用。值得注意的是，有三个 TE 与假定的增强子区域重叠，这表明它们对基因表达有潜在的调控作用。这些发现凸显了TEs的调控潜力及其在胎盘发育中的重要性，支持TE失调可能导致PE发病。

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Three transposable elements exhibiting differential expression in pre-eclampsia overlap with enhancer regions

Transposable elements (TEs) play a crucial role in placental development and dysfunction. Our study examined TE expression in pre-eclampsia (PE) using RNA-seq datasets. We identified differentially expressed TEs and explored the genomic location of the most significant TEs, investigating their possible regulatory roles. Notably, three TEs overlapped with putative enhancer regions, suggesting a potential regulatory impact on gene expression. These findings highlight the regulatory potential of TEs and their importance in placental development, supporting that TE dysregulation may contribute to PE pathogenesis.

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来源期刊

Placenta 医学-发育生物学

CiteScore

6.30

自引率

10.50%

发文量

391

审稿时长

78 days

期刊介绍： Placenta publishes high-quality original articles and invited topical reviews on all aspects of human and animal placentation, and the interactions between the mother, the placenta and fetal development. Topics covered include evolution, development, genetics and epigenetics, stem cells, metabolism, transport, immunology, pathology, pharmacology, cell and molecular biology, and developmental programming. The Editors welcome studies on implantation and the endometrium, comparative placentation, the uterine and umbilical circulations, the relationship between fetal and placental development, clinical aspects of altered placental development or function, the placental membranes, the influence of paternal factors on placental development or function, and the assessment of biomarkers of placental disorders.