评估视网膜色素变性患者腱膜下自体富血小板血浆疗法的疗效及影响治疗反应的因素。

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
Esra Sahli, Emin Özmert, Murat Doğuş Günel, Huban Atilla
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引用次数: 0

摘要

目的:评估自体血小板丰富血浆(PRP)治疗视网膜色素变性(RP)患者的效果,并确定影响治疗反应的因素:为此,研究纳入了 43 名视力在 1 logMAR 及以上的视网膜色素变性患者的 85 只眼睛,并进行了 3 次腱膜下自体血小板丰富血浆治疗,每次间隔两周。除了全面的眼科检查外,还对患者进行了视力、视野、视网膜中央灵敏度测量、视网膜电图(ERG)等功能测试,以及视网膜外层厚度、光学相干断层扫描中椭圆形区的长度、眼底自动荧光成像(FAF)中高自发荧光环的尺寸等结构测量:结果:患者的视力、视野 MD 和 PSD 指数以及暗适应 10.0 ERG 反应 b 波振幅均有统计学意义的明显改善。视网膜中央平均灵敏度、固定稳定性、视网膜外层厚度和椭球区长度均无明显变化。用 FAF 测量的高荧光环的直径和面积也没有发现有统计学意义的变化。研究发现,患者的年龄和发病年龄是影响治疗反应的参数:结论:通过定期对 RP 患者进行 PRP 治疗,可以改善视功能并阻止疾病的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the efficacy of subtenon autologous platelet-rich plasma therapy in patients with retinitis pigmentosa and factors affecting response to the treatment.

Purpose: To evaluate the effect of subtenon platelet-rich plasma (PRP) treatment in retinitis pigmentosa (RP) patients and to determine the factors affecting the response to treatment.

Methods: For this purpose, 85 eyes of 43 RP patients with visual acuity of 1 logMAR and above were included in the study and subtenon autologous PRP treatment was applied 3 times at two-week intervals. In addition to a full ophthalmological examination, functional tests such as visual acuity, visual field, central retinal sensitivity measurement, and electroretinography (ERG) and structural measurements including the thickness of the outer retinal layers, and the length of the ellipsoid zone in optic coherence tomography, and the dimensions of the hyperautofluorescent ring in fundus autofluorescence imaging (FAF) were performed on the patients before and one month after the treatment.

Results: A statistically significant improvement was achieved in the patient's visual acuity, visual field MD and PSD index, and dark-adapted 10.0 ERG response b wave amplitude. There was no significant change in average central retinal sensitivity, fixation stability, outer retinal layer thickness and ellipsoid zone length. No statistically significant change was detected in the diameter and area of the hyperautofluorescence ring measured by FAF. It was found that the age of the patients and the age of onset of the disease were parameters affecting the treatment response.

Conclusion: With PRP treatment applied periodically in RP patients, it may be possible to improve visual function and stop the progression of the disease, which can be detected by structural evaluations.

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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
451
期刊介绍: International Ophthalmology provides the clinician with articles on all the relevant subspecialties of ophthalmology, with a broad international scope. The emphasis is on presentation of the latest clinical research in the field. In addition, the journal includes regular sections devoted to new developments in technologies, products, and techniques.
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