在北极狼(Canis lupus arctos)中发现一种新型副病毒。

Polish journal of microbiology Pub Date : 2024-09-13 eCollection Date: 2024-09-01 DOI:10.33073/pjm-2024-035
Ziyuan Dai, Qiang Lu, Mingzhong Sun, Hongmei Chen, Rong Zhu, Huiqing Wang
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引用次数: 0

摘要

在从中国北极狼(Canis lupus arctos)咽部元基因组文库中发现了一种新型病毒,暂命名为 "北极狼副病毒"(AWPV)。其基因组序列的GenBase登录号为C_AA071902.1。AWPV 的基因组由 4,920 个碱基对组成,核苷酸组成为 36.4% A、23.4% T、18.2% G 和 22.0% C,GC 含量为 40.2%。它的结构类似于副病毒,包含两个开放阅读框:编码复制酶的非结构(NS)区和编码噬菌体蛋白的结构(VP)区。成对序列比较和系统进化分析表明,AWPV 可能是原尖头病毒属中的一个新物种。这一发现加深了我们对哺乳动物病毒生态学和未来潜在传染病的了解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of a Novel Parvovirus in the Arctic Wolf (Canis lupus arctos).

A novel virus, temporarily named "Arctic wolf parvovirus" (AWPV), was discovered in a pharyngeal metagenomic library derived from an Arctic wolf (Canis lupus arctos) in China. The genome sequence was assigned GenBase accession number C_AA071902.1. AWPV has a genome comprised of 4,920 base pairs with a nucleotide composition of 36.4% A, 23.4% T, 18.2% G, and 22.0% C, with a GC content of 40.2%. Its structure resembles parvoviruses, containing two open reading frames: the nonstructural (NS) region encoding replication enzymes and the structural (VP) region encoding capsid protein. Pairwise sequence comparison and phylogenetic analysis suggest AWPV may represent a novel species within the genus Protoparvovirus. This discovery enhances our understanding of mammalian virus ecology and potential future infectious diseases.

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