{"title":"血清蛋白模式与阿尔茨海默病的未来诊断有关。","authors":"","doi":"10.1038/s43587-024-00723-y","DOIUrl":null,"url":null,"abstract":"Insights into the Alzheimer’s disease blood proteome from a population-based cohort show how the serum levels of certain proteins change prior to diagnosis, how they overlap with signature changes in disease-relevant tissues, and how the association between certain proteins and the disease markedly shifts according to APOE-ε4 carrier status.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0000,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Serum protein patterns are associated with future diagnosis of Alzheimer’s disease\",\"authors\":\"\",\"doi\":\"10.1038/s43587-024-00723-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Insights into the Alzheimer’s disease blood proteome from a population-based cohort show how the serum levels of certain proteins change prior to diagnosis, how they overlap with signature changes in disease-relevant tissues, and how the association between certain proteins and the disease markedly shifts according to APOE-ε4 carrier status.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00723-y\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00723-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Serum protein patterns are associated with future diagnosis of Alzheimer’s disease
Insights into the Alzheimer’s disease blood proteome from a population-based cohort show how the serum levels of certain proteins change prior to diagnosis, how they overlap with signature changes in disease-relevant tissues, and how the association between certain proteins and the disease markedly shifts according to APOE-ε4 carrier status.
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