性别对产后生长受限大鼠代谢和神经发育参数的影响

Faiza Ikram, Muhammad Ali Rabani, Sidra Arshad, Barkat Ullah Khan, Muhammad Usman Bashir
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摘要

目的研究设计:随机对照试验。研究地点和时间CMH 木尔坦医学科学院,2021 年 9 月至 2021 年 12 月:这项研究包括 142 只新生维斯特大鼠,它们被分成不同的亚组,以模拟人类早产儿产后营养不良和追赶生长的模型。代谢后果通过血清葡萄糖、瘦素和三酰甘油分析进行评估。通过被动回避测试对亚组进行神经认知比较。各亚组间所有定量参数的比较均按性别进行:结果:加速追赶生长的营养不良大鼠的体重增加与正常喂养的大鼠相似,雄性(p = 0.92)和雌性(p >0.99)的体重增加与正常喂养的大鼠相似。与不进行或正常进行追赶生长的大鼠相比,进行加速追赶生长的大鼠空腹血清葡萄糖水平更高(p 结论:加速追赶生长能有效地提高大鼠的体重增加速度:加速追赶生长能有效解决躯体生长差异,而正常追赶生长则能提供更有利的代谢和神经发育结果。特别是,营养不良的雌性大鼠在加速生长和不加速生长的情况下神经发育都很差。神经发育的性别差异凸显了早产儿营养护理中个性化护理方法的必要性:生长迟缓 瘦素 宫外生长受限 营养不良 神经发育
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Gender on Metabolic and Neurodevelopmental Parameters of Postnatally Growth-Restricted Rats Undergoing Catch-Up Growth.

Objective: To determine the long-term effects of early postnatal malnutrition and various degrees of catch-up growth on metabolic (serum glucose, leptin, triacylglycerides) and neurodevelopmental parameters (learning and memory) among male and female rodent models, mimicking human preterm infants.

Study design: Randomized controlled trial. Place and Duration of the Study: CMH Multan Insitute of Medical Sciences, from September 2021 to December 2021.

Methdology: This study included 142 neonatal Wister rats, stratified into subgroups to mimic the human preterm infant model of postnatal malnutrition and catch-up growth. Metabolic consequences were assessed via serum analysis of glucose, leptin, and triacylglycerides. The neurocognitive comparison was made among subgroups via a passive avoidance test. Gender-specific comparison of all quantitative parameters was made among subgroups.

Results: Malnourished rats with accelerated catch-up growth achieved similar weight gain as normally fed rats when provided with adlibitum feeding in both males (p = 0.92) and females (p >0.99). Rats undergoing accelerated catch-up growth exhibited higher fasting serum glucose levels compared to those undergoing no, or normal catch-up growth (p <0.001). Malnourished female rats undergoing accelerated (p = 0.007), or no catchup growth (p = 0.004) exhibited significant deficits in learning and memory as compared to normally fed rats. Female malnourished rats with normal catchup growth exhibited no neurocognitive deficit as compared to normally fed rats (p = 0.08).

Conclusion: Accelerated catch-up growth effectively addresses somatic growth disparities, while normal catch-up growth offers more favourable metabolic and neurodevelopmental outcomes. Particularly, female malnourished rats exhibited poor neurodevelopment in response to both accelerated and no catch-up growth. Gender-specific variations in neurodevelopment underscore the need for personalised care approaches for preterm nutritional care.

Key words: Growth retardation, Leptin, Extrauterine growth restriction, Malnutrition, Neurodevelopment.

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